Association between diabetes and tuberculosis: case-control study

Authors

  • Susan Martins Pereira Universidade Federal da Bahia; Instituto de Saúde Coletiva
  • Gleide Santos de Araújo Universidade Federal da Bahia; Instituto de Saúde Coletiva
  • Carlos Antônio de Souza Teles Santos Fundação Osvaldo Cruz; Centro de Pesquisa Gonçalo Moniz
  • Maeli Gomes de Oliveira Universidade Estadual de Feira de Santana; Departamento de Saúde
  • Maurício Lima Barreto Fundação Osvaldo Cruz; Centro de Pesquisa Gonçalo Moniz

DOI:

https://doi.org/10.1590/s1518-8787.2016050006374

Abstract

OBJECTIVE To test the association between diabetes and tuberculosis. METHODS It is a case-control study, matched by age and sex. We included 323 new cases of tuberculosis with positive results for bacilloscopy. The controls were 323 respiratory symptomatic patients with negative bacilloscopy, from the same health services, such as: ambulatory cases from three referral hospitals and six basic health units responsible for the notifications of new cases of tuberculosis in Salvador, Bahia. Data collection occurred between 2008 and 2010. The instruments used were structured interview, including clinical data, capillary blood glucose (during fasting or postprandial), and the CAGE questionnaire for screening of abusive consumption of alcohol. Descriptive, exploratory, and multivariate analysis was performed using conditional logistic regression. RESULTS The average age of the cases was 38.5 (SD = 14.2) years and of the controls, 38.5 (SD = 14.3) years. Among cases and controls, most subjects (61%) were male. In univariate analysis we found association between the occurrence of diabetes and tuberculosis (OR = 2.37; 95%CI 1.04–5.42), which remained statistically significant after adjustment for potential confounders (OR = 3.12; 95%CI 1.12–7.94). CONCLUSIONS The association between diabetes and tuberculosis can hinder the control of tuberculosis, contributing to the maintainance of the disease burden. The situation demands increasing early detection of diabetes among people with tuberculosis, in an attempt to improve disease control strategies.

Published

2016-01-01

How to Cite

Pereira, S. M., Araújo, G. S. de, Santos, C. A. de S. T., Oliveira, M. G. de, & Barreto, M. L. (2016). Association between diabetes and tuberculosis: case-control study. Revista De Saúde Pública, 50, 82. https://doi.org/10.1590/s1518-8787.2016050006374

Issue

Section

Original Articles