Neurodevelopment in the third year of life in children with antenatal ZIKV-exposure

Carolina Yuri Panvequio  Aizawa; Deyse Mayara Rodrigues  Caron; Carolina Barbosa  Souza; Paula Fernanda Augusto Kozima; Luana Damasceno; Christa Einspieler; Peter B. Marschik; Patrícia Brasil; Ana Carolina Basso Schmitt; Karin Nielsen-Saines; Renata Hydee Hasue

doi:10.11606/s1518-8787.2021055002798

Authors

Carolina Yuri Panvequio Aizawa Universidade de São Paulo. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Reabilitação. São Paulo, SP, BR https://orcid.org/0000-0003-3907-1554
Deyse Mayara Rodrigues Caron Universidade de São Paulo. Faculdade de Medicina. Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional. São Paulo, SP, BR https://orcid.org/0000-0003-1878-5873
Carolina Barbosa Souza Universidade de São Paulo. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Reabilitação. São Paulo, SP, BR https://orcid.org/0000-0001-6064-2142
Paula Fernanda Augusto Kozima Universidade de São Paulo. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Reabilitação. São Paulo, SP, BR https://orcid.org/0000-0002-4150-3638
Luana Damasceno Fundação Oswaldo Cruz – FIOCRUZ. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BR https://orcid.org/0000-0003-1724-598X
Christa Einspieler Medical University of Graz. Division of Phoniatrics. iDN – interdisciplinary Developmental Neuroscience. Graz, Austria https://orcid.org/0000-0002-7875-0632
Peter B. Marschik Medical University of Graz. Division of Phoniatrics. iDN – interdisciplinary Developmental Neuroscience. Graz, Austria https://orcid.org/0000-0001-8932-0980
Patrícia Brasil Fundação Oswaldo Cruz – FIOCRUZ. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BR https://orcid.org/0000-0001-9555-7976
Ana Carolina Basso Schmitt Universidade de São Paulo. Faculdade de Medicina. Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional. São Paulo, SP, BR https://orcid.org/0000-0003-3685-6735
Karin Nielsen-Saines University of California Los Angeles. David Geffen School of Medicine. Department of Pediatrics. Los Angeles, CA, USA https://orcid.org/0000-0002-1742-5211
Renata Hydee Hasue Universidade de São Paulo. Faculdade de Medicina. Departamento de Fisioterapia, Fonoaudiologia e Terapia Ocupacional. São Paulo, SP, BR https://orcid.org/0000-0002-7717-6042

DOI:

https://doi.org/10.11606/s1518-8787.2021055002798

Keywords:

Child development, Language development, Cognition, Motor activity, Zika virus

Abstract

We report cognitive, language and motor neurodevelopment, assessed by the Bayley-III test, in 31 non-microcephalic children at age 3 with PCR-confirmed maternal Zika virus exposure (Rio de Janeiro, 2015–2016). Most children had average neurodevelopmental scores, however, 8 children (26%) presented delay in some domain. Language was the most affected: 7 children (22.6%) had a delay in this domain (2 presenting severe delay). Moderate delay was detected in the cognitive (3.2%) and motor (10%) domains. Maternal illness in the third trimester of pregnancy and later gestational age at birth were associated with higher Bayley-III scores. Zika-exposed children require long-term follow-up until school age.

References

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Neurodevelopment in the third year of life in children with antenatal ZIKV-exposure

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