Peso ao nascer e densidade mineral óssea aos 18–19 anos: coorte de nascimentos 1997–1998

Allanne Pereira Araújo; Janaina Maiana Abreu  Barbosa; Carolina Abreu de  Carvalho; Poliana Cristina de Almeida Fonseca Viola; Cecilia Claudia Costa Ribeiro; Rosangela Fernandes Lucena  Batista; Vanda Maria Ferreira Simões

doi:10.11606/s1518-8787.2023057004179

Authors

Allanne Pereira Araújo Universidade Federal do Maranhão. Programa de Pós Graduação em Saúde Coletiva. São Luís, MA, Brasil https://orcid.org/0000-0003-3697-1629
Janaina Maiana Abreu Barbosa Universidade Federal do Maranhão. Programa de Pós Graduação em Saúde Coletiva. São Luís, MA, Brasil https://orcid.org/0000-0001-5263-6586
Carolina Abreu de Carvalho Universidade Federal do Maranhão. Departamento de Saúde Pública. São Luís, MA, Brasil https://orcid.org/0000-0001-7900-4642
Poliana Cristina de Almeida Fonseca Viola Universidade Federal do Piauí. Departamento de Nutrição. Teresina, PI, Brasil https://orcid.org/0000-0002-8875-5154
Cecilia Claudia Costa Ribeiro Universidade Federal do Maranhão. Departamento de Saúde Pública. São Luís, MA, Brasil https://orcid.org/0000-0003-0041-7618
Rosangela Fernandes Lucena Batista Universidade Federal do Maranhão. Departamento de Saúde Pública. São Luís, MA, Brasil https://orcid.org/0000-0002-1529-0165
Vanda Maria Ferreira Simões Universidade Federal do Maranhão. Departamento de Saúde Pública. São Luís, MA, Brasi https://orcid.org/0000-0001-8351-1348

DOI:

https://doi.org/10.11606/s1518-8787.2023057004179

Keywords:

Adolescent, Bone Density, Birth Weight, Cohort Studies

Abstract

OBJECTIVE: To analyze the association between birth weight and bone mineral density (BMD) in adolescence.

METHODS: A birth cohort study in São Luís, Maranhão, using data from two moments: at birth and at 18–19 years. Exposure was the birth weight in grams, continuously analyzed. The outcome was BMD, using the Z-score index (whole body) measured by double X-ray densitometry (DEXA). A theoretical model was constructed in acyclic graphs to identify the minimum set of adjustment variables – household income, the mother knowing how to read and write at the time of birth, prenatal care, tobacco use during pregnancy, and parity — to evaluate the association between birth weight and bone mineral density in adolescence. Multiple linear regression was used in Stata 14.0 software. A 5% significance level was adopted.

RESULTS: From 2,112 adolescents, 8.2% had low birth weight and 2.8% had a low BMD for their age. The mean full-body Z-score was 0.19 (±1.00). The highest birth weight was directly and linearly associated with BMD values in adolescence (Coef.: 0.10; 95%CI: 0.02–0.18), even after adjustment for the variables household income (Coef.: −0.33; 95%CI: 0.66–0.03) and the mother knowing how to read and write (Coef.: 0.23%; 95%CI: 0.03–0.43).

CONCLUSION: Although after adjusting the variables the association attenuated, birth weight positively and linearly relates to BMD in adolescence.

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Birth weight and bone mineral density at 18–19 years: birth cohort 1997–1998

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