Possible interference of pre-existing tetanus antitoxin in antitetanus immunization
DOI:
https://doi.org/10.1590/S0034-89101981000200005Keywords:
Tetanus^i2^sguinea pigs and m, Tetanus antitoxin, Tetanus toxoidAbstract
Possibility of interference in the development of active antitetanic immunity was studied in the offspring of guinea pigs and mice whose mothers had received antitetanic vaccine during different periods of pregnancy. Vaccination of the females during pregnancy did not interfere negatively in the development of active immunity in their offspring when the latter were vaccinated about 60 days after birth. The presence of small amounts of circulating antibodies, congenitally received, seems, under certain conditions, to stimulate the immune response upon posterior vaccination against tetanus. This suggests that the acquired antigen-antibody complex heightens the immune response induced by the toxoid.Downloads
Published
1981-04-01
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Section
Original Articles
How to Cite
Guidolin, R., Zelante, F., Medeiros, E. H. G. R., & Lacreta, P. R. V. (1981). Possible interference of pre-existing tetanus antitoxin in antitetanus immunization . Revista De Saúde Pública, 15(2), 205-210. https://doi.org/10.1590/S0034-89101981000200005