The evolution of immunoglobulins involved in the immune response to mice infected with Schistosoma mansoni

Authors

  • Othon de Carvalho Bastos Universidade Federal do Maranhão
  • Humberto de Araújo Rangel Universidade Estadual de Campinas
  • Luiz Augusto Magalhães Universidade Estadual de Campinas
  • Aquiles Eugênico Piedrabuena Universidade Estadual de Campinas

DOI:

https://doi.org/10.1590/S0034-89101984000200006

Keywords:

Schistosoma mansoni, Immunoglobulins, Schistosomiasis

Abstract

The evolution of immunoglobulins involved in the immune response of mice infected with Schistosoma mansoni was studied by using plurispecific sera and the bi-dimensional immunoelectrophoresis technique. Determinations of the level of different immunoglobulins in infected animals and control groups which were mantained under similar conditions detected significant variations in both groups over the 8 weeks of observation. The study of the relationship (I/C) between the level of immunoglobulins of the infected animals (I) and that of corresponding control (C) showed that the infected animals presented a primary response (1-2 weeks after infection date) and a secondary response that was initiated in the 6th week of infection, with levels of IgA, IgG and IgM that were respectively 4.5, 3 and 2 times higher than those of corresponding control.

Published

1984-04-01

Issue

Section

Original Articles

How to Cite

The evolution of immunoglobulins involved in the immune response to mice infected with Schistosoma mansoni . (1984). Revista De Saúde Pública, 18(2), 138-154. https://doi.org/10.1590/S0034-89101984000200006