The use of a semipurified fraction of Trypanosoma cruzi proteinase in immunodiagnosis of Chagas' disease

Authors

  • Ajax Mercês Atta Universidade Federal da Bahia; Faculdade de Farmácia; Departamento de Farmácia Qualitatica
  • Angela Maria de Carvalho Pontes Universidade Federal da Bahia; Faculdade de Farmácia; Departamento de Farmácia Qualitatica
  • Maria Luiza de Souza Universidade Federal da Bahia; Faculdade de Farmácia; Departamento de Farmácia Qualitatica
  • Daria Repka Universidade Estadual de Campinas; Instituto de Biologia; Departamento de Microbiologia e Imunologia
  • Humberto A. Rangel Universidade Estadual de Campinas; Instituto de Biologia; Departamento de Microbiologia e Imunologia

DOI:

https://doi.org/10.1590/S0034-89101984000600007

Keywords:

Trypanosomiasis, South American^i2^sdiagno, Trypanosoma cruzi, Peptide peptidohydrolases

Abstract

Group 0 Rh negative human erytrocytes were coated with the semipurified fraction of T. cruzi proteinase and tested with sera both from patients with chagas' disease and from others with unrelated parasitic diseases. Positive haemagglutination reactions were only observed with the sera from the former and with that from two patients with mucocutaneous leishmaniasis. No crossed reactions were observed with visceral leishmaniasis, malaria, toxoplasmosis syphilis, schistosomiasis or mononucleosis sera. Results suggest that this purified fraction can be used in immunodiagnosis of American Trypanosomiasis.

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Published

1984-12-01

Issue

Vol. 18 No. 6 (1984)

Section

Original Articles

How to Cite

Atta, A. M., Pontes, A. M. de C., Souza, M. L. de, Repka, D., & Rangel, H. A. (1984). The use of a semipurified fraction of Trypanosoma cruzi proteinase in immunodiagnosis of Chagas’ disease . Revista De Saúde Pública, 18(6), 487-490. https://doi.org/10.1590/S0034-89101984000600007