Sterilization of sera and vaccines by cobalt gamma radiation

Authors

  • Rosalvo Guidolin Instituto Butantan
  • Alcino Corrêa Syntex do Brasil
  • Regina Maria Barreto Cicarelli Faculdade de Farmácia e Odontologia de Araraquara
  • Eloi Previde IBRAS - CBO. Indústrias Cirúrgicas e Ópticas S.A.
  • Josefina Farina Morais Instituto Butantan
  • Hisako Gondo Higashi Instituto Butantan

DOI:

https://doi.org/10.1590/S0034-89101988000200007

Keywords:

Sterilization^i2^smeth, Gamma rays, Tetanus toxoid^i2^sradiation effe, Diphteria toxoid^i2^sradiation effe, Pertussis vaccine^i2^sradiation effe, Tetanus antitoxin^i2^sradiation effe, Diphteria antitoxin^i2^sradiation effe, Antivenin^i2^sradiation effe

Abstract

Diphteria, tetanus, anti-snake venom sera and Diphteria-Pertussis-Tetanus vaccine were submited to different intensities of gamma radiation, in order to: verify the resistance of their specific activities to the action of gamma rays; evaluate the possibility of using this type of energy to sterilize some heterogenous hyperimmune sera and vaccines commonly utilized in Public Health. The results, according to the range employed, show the possibility of sterilizing the products tested, without any alteration to specific biological and chemical properties.

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Published

1988-04-01

Issue

Vol. 22 No. 2 (1988)

Section

Original Articles

How to Cite

Guidolin, R., Corrêa, A., Cicarelli, R. M. B., Previde, E., Morais, J. F., & Higashi, H. G. (1988). Sterilization of sera and vaccines by cobalt gamma radiation . Revista De Saúde Pública, 22(2), 113-117. https://doi.org/10.1590/S0034-89101988000200007