Comparative study of the susceptibility of human diploid cell strains to the cytomegalovirus

Abstract

A comparative study of the susceptibility of different strains of human diploid cells (FH1, FH3, FH4, FH11, FH13, FH14, FH15) to cytomegalovirus disclosed a relation between the capacity of growing and producing a consistent cytophatic effect of human cytomegalovirus strains and the homogeneous characteristics of the tissue cultures. The cell strains FH3 and FH16 were insusceptible when fibroblasts and epithelial cells were present in the same culture. After a certain number of passages, when the fibroblastic characteristics of cells in the cultures was established, the cytophatic effect could be consistently observed.