Advanced chronic lymphoid leukemia with severe bronchopneumonia: an Autopsy Case Report

Authors

  • Felipe Gomes Campos Amaral University of São Paulo. Faculty of Medicine. Anatomic Pathology Department
  • Luiz Guilherme Cernaglia Aureliano Lima University of São Paulo. Faculty of Medicine. Instituto do Câncer do Estado de São Paulo
  • Veruska Menegatti Anastacio Hatanaka University of São Paulo. Faculty of Medicine. Instituto do Câncer do Estado de São Paulo
  • Sheila Aparecida Coelho Siqueira University of São Paulo. Faculty of Medicine. Anatomic Pathology Department
  • Amaro Nunes Duarte-Neto University of São Paulo. Faculty of Medicine. Anatomic Pathology Department - University of São Paulo. Faculty of Medicine. Hospital das Clínicas. Emergency Department

DOI:

https://doi.org/10.4322/acr.2016.022

Keywords:

Leukemia, Lymphocytic, Chronic, B-Cell, Respiratory Insufficiency, Pneumonia, Autopsy

Abstract

Chronic lymphocytic leukemia (CLL) is a lymphoid neoplasia with the B immunophenotype, which corresponds to the leukemic form of lymphocytic lymphoma. This entity is characterized, in most cases, by immunosuppression due to impaired function of immune cells, hypogammaglobulinemia, bone marrow infiltration, and immune dysfunction due to the neoplasia and the chemotherapy, when prescribed. We describe the case of a 63-year-old woman with a previous diagnosis of advanced CLL, refractory to treatment, who presented respiratory failure at the emergency department and died soon after hospital admission. The autopsy examination showed a large retroperitoneal mass compressing large vessels and abdominal and pelvic organs; generalized lymphadenopathy; and liver, spleen, bone marrow, heart and kidney infiltration. A Gram-negative bacilli bronchopneumonia with diffuse alveolar damage was detected, which was likely to be the immediate cause of death

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Published

2016-03-10

How to Cite

Amaral, F. G. C., Lima, L. G. C. A., Hatanaka, V. M. A., Siqueira, S. A. C., & Duarte-Neto, A. N. (2016). Advanced chronic lymphoid leukemia with severe bronchopneumonia: an Autopsy Case Report. Autopsy and Case Reports, 6(1), 11-20. https://doi.org/10.4322/acr.2016.022

Issue

Section

Article / Autopsy Case Report