Indeterminate cell histiocytosis successfully treated with phototherapy

Authors

  • Maria Claudia Nogueira Zerbini University of São Paulo. Faculty of Medicine. Department of Pathology
  • Mirian Nacagami Sotto University of São Paulo. Faculty of Medicine. Department of Pathology
  • Fernando Peixoto Ferraz de Campos University of São Paulo. Hospital Universitário. Internal Medicine Division
  • Andre Neder Ramires Abdo Instituto do Câncer de São Paulo. Hematologic Oncology Department
  • Juliana Pereira Instituto do Câncer de São Paulo. Hematologic Oncology Department Universisity of São Paulo. Faculty of Medicine. Department of Hematology
  • José Antônio Sanches Junior University of São Paulo. Hospital das Clínicas. Faculty of Medicine. Dermatology Department
  • Jade Cury Martins University of São Paulo. Hospital das Clínicas. Faculty of Medicine. Dermatology Department

DOI:

https://doi.org/10.4322/acr.2016.038

Keywords:

Histiocytosis, Skin Diseases, Phototherapy

Abstract

First described in 1985, intermediate cell histiocytosis is a rare disorder of the cutaneous dendritic cell group with a varied clinical presentation and evolution. The pathologic substrate is constituted by the proliferation of indeterminate cells (ICs) that are immunophenotypically characterized by the positivity of CD1a, CD68, and faint/focal S100, plus the negativity for CD207 (langerin). The authors present the case of a healthy elderly woman who presented generalized dome-shaped reddish cutaneous nodules over her trunk, neck, face, and extremities over a period of 18 months. A laboratory and imaging work-up ruled out internal involvement. The skin biopsy was consistent with IC histiocytosis. The patient was treated with narrowband ultraviolet B phototherapy, which resulted in an excellent short-term outcome

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Published

2016-06-11

How to Cite

Zerbini, M. C. N., Sotto, M. N., Campos, F. P. F. de, Abdo, A. N. R., Pereira, J., Sanches Junior, J. A., & Martins, J. C. (2016). Indeterminate cell histiocytosis successfully treated with phototherapy. Autopsy and Case Reports, 6(2), 33-38. https://doi.org/10.4322/acr.2016.038

Issue

Section

Article / Clinical Case Report