Gastrointestinal cytomegalovirus disease in a patient with pemphigus vulgaris treated with corticosteroid and mycophenolate mofetil

Authors

  • Luiza Barbosa Oliveira Universidade de São Paulo. Faculty of Medicine. Anatomic Pathology Department. Autopsy Division
  • Celina Wakisaka Maruta Universidade de São Paulo. Faculty of Medicine. Department of Dermatology
  • Denise Miyamoto Universidade de São Paulo. Faculty of Medicine. Department of Dermatology
  • Fernanda Aburesi Salvadori Universidade de São Paulo. Faculty of Medicine. Hospital das Clínicas. Emergency Department
  • Claudia Giuli Santi Universidade de São Paulo. Faculty of Medicine. Department of Dermatology
  • Valeria Aoki Universidade de São Paulo. Faculty of Medicine. Department of Dermatology
  • Amaro Nunes Duarte-Neto Universidade de São Paulo. Faculty of Medicine. Anatomic Pathology Department. Autopsy Division Universidade de São Paulo. Faculty of Medicine. Hospital das Clínicas. Emergency Department

DOI:

https://doi.org/10.4322/acr.2017.008

Keywords:

Autopsy, Cytomegalovirus, Opportunistic Infections, Pemphigus

Abstract

Pemphigus vulgaris is an autoimmune disease characterized by the formation of suprabasal intra-epidermal blisters on the skin and mucosal surfaces. Infectious diseases are the main cause of death in patients with pemphigus due to the disrupture of the physiological skin barrier, immune dysregulation, and the use of immunosuppressive medications leaving the patient prone to acquire opportunistic infections. We report the case of a 67-year-old woman diagnosed with pemphigus vulgaris, who was irregularly taking prednisone and mycophenolate mofetil. She was hospitalized because of a 1-month history of watery diarrhea and oral ulcers. Unfortunately, the patient died suddenly on the ward. The autopsy revealed a bilateral saddle pulmonary embolism, Gram-positive cocci bronchopneumonia, and gastrointestinal cytomegalovirus infection, causing extensive gastrointestinal mucosal ulcers

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Published

2017-03-29

How to Cite

Oliveira, L. B., Maruta, C. W., Miyamoto, D., Salvadori, F. A., Santi, C. G., Aoki, V., & Duarte-Neto, A. N. (2017). Gastrointestinal cytomegalovirus disease in a patient with pemphigus vulgaris treated with corticosteroid and mycophenolate mofetil. Autopsy and Case Reports, 7(1), 23-30. https://doi.org/10.4322/acr.2017.008

Issue

Section

Article / Autopsy Case Report