EBV-negative lymphoepithelial-like carcinoma of the lower lip

Authors

  • Luciana Yamamoto Almeida Universidade Estadual de São Paulo, Faculdade de Odontologia de Araraquara, Medicina Oral, Departamento de Diagnóstico e Cirurgia https://orcid.org/0000-0001-5403-4052
  • Heitor Albergoni Silveira Universidade Estadual de São Paulo, Faculdade de Odontologia de Araraquara, Medicina Oral, Departamento de Diagnóstico e Cirurgia https://orcid.org/0000-0002-6724-3504
  • Evânio Vilela Silva Universidade Estadual de São Paulo, Faculdade de Odontologia de Araraquara, Medicina Oral, Departamento de Diagnóstico e Cirurgia https://orcid.org/0000-0001-9883-9776
  • Camila de Oliveira Barbeiro Universidade Estadual de São Paulo, Faculdade de Odontologia de Araraquara, Medicina Oral, Departamento de Diagnóstico e Cirurgia https://orcid.org/0000-0002-8166-0101
  • Joaquim Augusto de Paula Ministério da Saúde do Brasil, Estratégia Saúde da Família
  • Andreia Bufalino Universidade Estadual de São Paulo, Faculdade de Odontologia de Araraquara, Medicina Oral, Departamento de Diagnóstico e Cirurgia https://orcid.org/0000-0002-6714-6253
  • Alfredo Ribeiro-Silva Ministério da Saúde do Brasil, Estratégia Saúde da Família https://orcid.org/0000-0002-3579-5048
  • Jorge Esquiche León Universidade de São Paulo (USP), Faculdade de Odontologia de Ribeirão Preto, Patologia Oral, Departamento de Estomatologia, Saúde Coletiva e Odontologia Legal https://orcid.org/0000-0002-9668-5870

DOI:

https://doi.org/10.4322/acr.2020.138

Keywords:

Immunohistochemistry, In Situ Hybridization, Lip diseases, Squamous Cell Carcinoma of Head and Neck

Abstract

Lymphoepithelial-like carcinoma (LEC) is a rare malignant neoplasm, which can be associated with Epstein-Barr virus (EBV) infection. Histologically, LEC is an undifferentiated carcinoma with an intermixed reactive lymphoplasmacytic infiltrate. LEC appears to be an uncommon tumor type of lip carcinoma. An 82-year-old white woman presented a lesion on her lower lip that developed over the last year. The lesion was characterized by ulceration with flat edges, hardened base, painful, and absence of regional lymphadenopathy. Microscopical analysis evidenced an intense inflammatory infiltrate, composed of lymphoplasmacytic cells, associated with scarce pleomorphic epithelial cells. Immunohistochemistry highlighted the LEC cells with strong expression of pan-CK AE1/AE3, EMA, p63, and p53. CD138 was also faintly positive. Ki-67 was >85%. In situ hybridization analysis did not show evidence of EBV. A diagnostic of EBV-negative LEC was made. We present an uncommon type of lip carcinoma, which can represent a diagnostic challenge for clinicians and pathologists.

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Published

2020-01-27

How to Cite

Almeida, L. Y., Silveira, H. A., Silva, E. V., Barbeiro, C. de O., Paula, J. A. de, Bufalino, A., Ribeiro-Silva, A., & León, J. E. (2020). EBV-negative lymphoepithelial-like carcinoma of the lower lip. Autopsy and Case Reports, 10(1), e2020138. https://doi.org/10.4322/acr.2020.138

Issue

Section

Article / Clinical Case Report