Nodal Epstein-Barr virus-positive T-cell/NK-cell lymphoma associated with immunodeficiency: a rare condition looking for recognition

Authors

  • Cristiane Rúbia Ferreira Anatomic Pathology Service – Hospital Universitário – Universidade de São Paulo, São Paulo/SP
  • Aloísio Felipe-Silva Anatomic Pathology Service – Hospital Universitário – Universidade de São Paulo, São Paulo/SP
  • Fernando Peixoto Ferraz de Campos Department of Internal Medicine – Hospital Universitário – Universidade de São Paulo, São Paulo/SP
  • Maria Cláudia Nogueira Zerbini Department of Pathology – Faculdade de Medicina – Universidade de São Paulo, São Paulo/SP

DOI:

https://doi.org/10.4322/acr.%25y.98463

Keywords:

Lymphoma, T-cell, Killer Cells, Natural, Epstein-Barr Virus Infections, Acquired Immunodeficiency Syndrome, Autopsy

Abstract

The authors describe a peculiar form of Epstein-Barr virus (EBV)-associated T-cell lymphoma in an HIV-positive patient presenting an aggressive clinical course. Unlike most other EBV-positive T-cell/natural-killer (NK)-cell lymphomas, the disease was characterized by predominant nodal involvement at presentation. T-cell lineage was confirmed by T-cell receptor-rearrangement, and neoplastic cells exhibited strong and diffuse CD56 expression. A marked intravascular component was detected in the skin, the liver, and the lung parenchyma. This entity was not predicted in the WHO 2008 classification, but has been recently identified in immunocompromised patients. This case report refers to a middle-aged man with AIDS, who presented a 4-month history of weight loss, fever, hepatosplenomegaly, peripheral and deep-chain lymphadenopathy. A blood smear showed lymphocytosis with a marked presence of atypia. The outcome was unfavorable and the patient could not be treated. The autopsy revealed multivisceral involvement, including lymph nodes, spleen, bone marrow, liver, lungs, skin, and kidneys.

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Published

2014-12-22

How to Cite

Ferreira, C. R., Felipe-Silva, A., Campos, F. P. F. de, & Zerbini, M. C. N. (2014). Nodal Epstein-Barr virus-positive T-cell/NK-cell lymphoma associated with immunodeficiency: a rare condition looking for recognition. Autopsy and Case Reports, 4(4), 25-34. https://doi.org/10.4322/acr.%y.98463

Issue

Section

Article / Autopsy Case Report