Self-emulsifying therapeutic system: a potential approach for delivery of lipophilic drugs
DOI:
https://doi.org/10.1590/S1984-82502011000300003Keywords:
Lipid based formulations, Self-emulsifying therapeutic system, Self-emulsificationAbstract
Self-emulsifying therapeutic system (SETs) provide an effective and intelligent solution to the various issues related to the formulation of hydrophobic drugs with limited solubility in gastrointestinal fluid. Although the potential utility of SETs is well known, only in recent years has a mechanistic understanding of the impact of these systems on drug disposition emerged. These in situ emulsion-forming systems have a high stability when incorporated in various dosage forms. SETs are being looked upon as systems which can overcome the problems associated with delivery of poorly water soluble drugs. An in-depth knowledge about lipids and surfactants that can contribute to these systems, criterion for their selection and the proportion in which they can be used, represent some crucial factors determining the in vivo performance of these systems. This article presents a comprehensive account of various types of self-emulsifying formulations with emphasis on their composition and examples of currently marketed preparations.Downloads
Download data is not yet available.
Downloads
Published
2011-09-01
Issue
Section
Reviews
License
All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.
The on line journal has open and free access.
How to Cite
Self-emulsifying therapeutic system: a potential approach for delivery of lipophilic drugs . (2011). Brazilian Journal of Pharmaceutical Sciences, 47(3), 447-465. https://doi.org/10.1590/S1984-82502011000300003