Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams

Authors

  • Karine Maria Boll State University of Londrina; University Hospital
  • Chiara Cristina Bortolasci State University of Londrina
  • Tiago Zaminelli State University of Londrina; Biological Sciences Center; Department of Physiological Sciences
  • Luiz Fernando Veríssimo State University of Londrina; Biological Sciences Center; Department of Physiological Sciences
  • André Demambre Bacchi State University of Londrina; Biological Sciences Center; Department of Physiological Sciences
  • Luciana Higachi State University of Londrina
  • Décio Sabbatini Barbosa State University of Londrina
  • Estefânia Gastaldello Moreira State University of Londrina; Biological Sciences Center; Department of Physiological Sciences

DOI:

https://doi.org/10.1590/S1984-82502014000200015

Abstract

Passiflora incarnata is marketed in many countries as a phytomedicine. Even though the directions of most marketed phytomedicines recommend them to be used under medical supervision, reproductive and developmental studies are sparse and not mandatory for regulatory purposes. In this study, a reproductive toxicity evaluation of P. incarnata was conducted in Wistar rats gavaged (30 or 300 mg/kg) during pregnancy and lactation. Moreover, considering that antioxidant properties have been attributed to flavonoids present in the genus Passiflora, it was also evaluated the antioxidant/pro-oxidant balance in the plasma of these dams and the antioxidant potential in an in vitro test. P. incarnata treatment did not influence dams´ body weight as well as reproductive (gestation length, post-implantation loss, litter size, litter weight) and hepatic (albumin, AST, ALT, GGT) parameters. The antioxidant property of P. incarnata was evidenced both in vivo (increase in the total antioxidant plasmatic potential) and in vitro (decrease in neutrophil-induced respiratory burst). The results from the present study indicate that under the experimental conditions evaluated, P. incarnata treatment during gestation and lactation presented antioxidant activity in the absence of maternal reproductive toxicity.

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Published

2014-04-01

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Section

Articles

How to Cite

Passiflora incarnata treatment during gestation and lactation: toxicological and antioxidant evaluation in wistar dams . (2014). Brazilian Journal of Pharmaceutical Sciences, 50(2), 353-359. https://doi.org/10.1590/S1984-82502014000200015