Methylparaben concentration in commercial Brazilian local anesthetics solutions

Autores

  • Gustavo Henrique Rodriguez da Silva University of Campinas; Institute of Chemistry; Department of Analytical Chemistry
  • Carla Beatriz Grespan Bottoli University of Campinas; Institute of Chemistry; Department of Analytical Chemistry
  • Francisco Carlos Groppo University of Campinas; Piracicaba Dental School; Department of Pharmacology, Anesthesiology and Therapeutics
  • Maria Cristina Volpato University of Campinas; Piracicaba Dental School; Department of Pharmacology, Anesthesiology and Therapeutics
  • José Ranali University of Campinas; Piracicaba Dental School; Department of Pharmacology, Anesthesiology and Therapeutics
  • Juliana Cama Ramacciato São Leopoldo Mandic Dental School; Department of Pharmacology, Anesthesiology and Therapeutics
  • Rogério Heládio Lopes Motta São Leopoldo Mandic Dental School; Department of Pharmacology, Anesthesiology and Therapeutics

DOI:

https://doi.org/10.1590/S1678-77572012000400009

Palavras-chave:

Hypersensitivity, Allergy, Local anesthetics

Resumo

OBJECTIVE: To detect the presence and concentration of methylparaben in cartridges of commercial Brazilian local anesthetics. MATERIAL AND METHODS: Twelve commercial brands (4 in glass and 8 in plastic cartridges) of local anesthetic solutions for use in dentistry were purchased from the Brazilian market and analyzed. Different lots of the commercial brands were obtained in different Brazilian cities (Piracicaba, Campinas and São Paulo). Separation was performed using high performance liquid chromatography (HPLC) with UV-Vis detector. The mobile phase used was acetonitrile:water (75:25 - v/v), pH 4.5, adjusted with acetic acid at a flow rate of 1.0 ml.min-1. RESULTS: When detected in the solutions, the methylparaben concentration ranged from 0.01% (m/v) to 0.16% (m/v). One glass and all plastic cartridges presented methylparaben. CONCLUSION: 1. Methylparaben concentration varied among solutions from different manufacturers, and it was not indicated in the drug package inserts; 2. Since the presence of methylparaben in dental anesthetics is not regulated by the Brazilian National Health Surveillance Agency (ANVISA) and this substance could cause allergic reactions, it is important to alert dentists about its possible presence.

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Publicado

2012-08-01

Edição

v. 20 n. 4 (2012)

Seção

Artigos Originais

Licença

Todo o conteúdo do periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons do tipo atribuição CC-BY.

 

 

Como Citar

Methylparaben concentration in commercial Brazilian local anesthetics solutions. (2012). Journal of Applied Oral Science, 20(4), 444-448. https://doi.org/10.1590/S1678-77572012000400009