Complex segregation analysis of 1,792 cleft lip and palate families in South America: 1967-1997
DOI:
https://doi.org/10.1590/S1517-74912003000200012Keywords:
Cleft palate, Craniofacial abnormalities, Abnormalities, Polygenic inheritanceAbstract
Although several studies have demonstrated familial aggregation of nonsyndromic cleft lip with or without cleft palate (CL/P), its model of inheritance remains uncertain. We report the results of complex segregation analysis performed in South American families with a newborn affected with CL/P. Families of 1,792 consecutive newborns affected with CL/P and registered during the period 1967 to 1997 were studied. A model that did not include a major locus was the best-fitting model for CL/P families. This result is in agreement with previous studies which showed a significant association of several putative susceptibility loci and CL/P, indicating that the genes involved in CL/P are likely to have only a very modest impact on disease risk.Downloads
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Published
2003-06-01
Issue
Section
Patologia
How to Cite
Complex segregation analysis of 1,792 cleft lip and palate families in South America: 1967-1997. (2003). Pesquisa Odontológica Brasileira, 17(2), 161-165. https://doi.org/10.1590/S1517-74912003000200012