Sensibility of evaluations of Malassezia furfur strains at cyclic imides

Abstract

Malassezia furfur (Pityrosporum orbiculare) is a lipophilic microrganism and it has also been associated with pityriasis versicolor, folliculitis, seborrheic and atopic dermatitis, fungemia and systemic infections. The treatment comprehends antimicotics or imidazol derivatives solutions, specially cetoconazol. With purpose of evaluating new alternatives to the therapeutics of mycosis infections, the antifungical activity of cyclic imides was determinated in the present study. The imides 3,4-cichloro-N-phenylmaleimide (6,3 µg/ml), 3,4dichloro-N-benzyl-maleimide (25 µg/mL) and 3,4dichloro-N-phenyl-propyl-maleimide (25 µg/mL) were the compounds which produced the best activities of inhibition against strains of M. furfur.