Effect of different doses of nandrolone associated with resistance training on muscle phenotypic profi le and cross-sectional area of rats

Authors

  • Rozangela Verlengia Universidade Metodista de Piracicaba; Faculdade de Ciências da Saúde
  • Jonato Prestes Universidade Católica de Brasília
  • Ricardo Yukio Asano Universidade Católica de Brasília
  • Wagner José da Silva Universidade Metodista de Piracicaba; Faculdade de Ciências da Saúde
  • Gerson Eduardo Rocha de Campos Universidade Metodista de Piracicaba; Faculdade de Ciências da Saúde
  • Cláudia Regina Cavaglieri Universidade Estadual de Campinas; Faculdade de Educação Física
  • Rodrigo Duarte de Souza Universidade Metodista de Piracicaba; Faculdade de Ciências da Saúde
  • Sérgio Ricardo Boff Universidade Metodista de Piracicaba; Faculdade de Ciências da Saúde
  • Silvia Cristina Crepaldi Alves Universidade Metodista de Piracicaba; Faculdade de Ciências da Saúde

DOI:

https://doi.org/10.1590/S1807-55092013000100009

Keywords:

Strength training, Anabolic steroid, Muscle fibers, Muscle cross-sectional area

Abstract

The aim of the present study was to evaluate the influence of different doses of nandrolone decanoate (ND) associated with Strength Training (ST) on the phenotype of fibers and cross-sectional area (CSA) of the extensor digitorum longus (EDL) in Wistar rats. The animals were divided into seven groups: control (CG) and the groups according to the dose of ND administered (0,1, 1, 2, 5, 10 e 20 mg/kg). The ST consisted of water jumping with loads of 50-70% of their body mass, three times per week during five weeks. The association of ST with ND promoted a modulatory role on the muscle fiber types. There was a hypertrophy of fast twitch fibers (type II) as compared with slow twitch (type I). In conclusion, although the association of ST with ND increased muscle CSA and modified fiber phenotype, there was no additional effect of higher doses.

Downloads

Download data is not yet available.

Downloads

Published

2013-03-01

Issue

Vol. 27 No. 1 (2013)

Section

Biodinâmica

License

Todo o conteúdo da revista, exceto onde está identificado, está licenciado sob uma Licença Creative Commons (CC-BY)

How to Cite

Verlengia, R., Prestes, J., Asano, R. Y., Silva, W. J. da, Campos, G. E. R. de, Cavaglieri, C. R., Souza, R. D. de, Boff, S. R., & Alves, S. C. C. (2013). Effect of different doses of nandrolone associated with resistance training on muscle phenotypic profi le and cross-sectional area of rats . Brazilian Journal of Physical Education and Sport, 27(1), 83-90. https://doi.org/10.1590/S1807-55092013000100009