Evaluation of the activity of albendazole in the therapy of experimentally-infected rats

Authors

  • Vicente Amato Neto Laboratório de Investigação Médica
  • Pedro Luiz Silva Pinto Universidade de São Paulo; Faculdade de Medicina; Departamento de Medicina Preventiva
  • Antonio Augusto Baillot Moreira Universidade de São Paulo; Faculdade de Medicina; Departamento de Medicina Preventiva
  • Rubens Campos Laboratório de Investigação Médica
  • Eunice José de Sant'ana Laboratório de Investigação Médica
  • Eduardo Virgilio Levai Universidade de São Paulo; Faculdade de Medicina; Departamento de Medicina Preventiva
  • Liliana Aparecida Araújo Padilha Laboratório de Investigação Médica
  • Clóvis Kiomitsu Takiguti Universidade de São Paulo; Faculdade de Medicina; Departamento de Medicina Preventiva

Abstract

In order to settle the precise spectrum of activity of albendazole, its efficacy was tested in the treatment of Strongyloides venezuelensis in experimentally-infected rats. The results were compared to those obtained with two other benzimidaloze derivatives, cambendazole and mebendazole. The three compounds were shown to be effective in eradicating intestinal adult worms completely, when single doses of 625, 12.5, 25 of 50 mg/kg were used. However when smaller doses were employed (5 mg/kg) worm burdens were reduced in 87%, 98% and 80% by albendazole, cambendazole and mebendazole respectively.

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Published

1986-06-01

Issue

Vol. 28 No. 3 (1986)

Section

Therapeutic Assays

How to Cite

Amato Neto, V., Pinto, P. L. S., Moreira, A. A. B., Campos, R., Sant'ana, E. J. de, Levai, E. V., Padilha, L. A. A., & Takiguti, C. K. (1986). Evaluation of the activity of albendazole in the therapy of experimentally-infected rats. Revista Do Instituto De Medicina Tropical De São Paulo, 28(3), 181-184. https://www.revistas.usp.br/rimtsp/article/view/101291