ROTAVIRUS GENOTYPES CIRCULATING IN BRAZIL, 2007-2012: IMPLICATIONS FOR THE VACCINE PROGRAM

Authors

  • Adriana LUCHS Adolfo Lutz Institute
  • Audrey CILLI Adolfo Lutz Institute
  • Simone Guadagnucci MORILLO Adolfo Lutz Institute
  • Rita de Cássia Compagnoli CARMONA Adolfo Lutz Institute
  • Maria do Carmo Sampaio Tavares TIMENETSKY Adolfo Lutz Institute

Abstract

Regarding public health in Brazil, a new scenario emerged with the establishment of universal rotavirus (RV) vaccination programs. Herein, the data from the five years of surveillance (2007-2012) of G- and P-type RV strains isolated from individuals with acute gastroenteritis in Brazil are reported. A total of 6,196 fecal specimens were investigated by ELISA and RT-PCR. RVs were detected in 19.1% (1,181/6,196). The peak of RV incidence moved from June-August to September. RV was detected less frequently (19.5%) among children ≤ 5 years than in older children and adolescents (6-18 years) (40.6%). Genotype distribution showed a different profile for each year: G2P[4] strains were most prevalent during 2007-2010, G9P[8] in 2011, and G12P[8] in 2012. Mixed infections (G1+G2P[4], G2+G3P[4]+P[8], G2+G12P[8]), unusual combinations (G1P[4], G2P[6]), and rare strains (G3P[3]) were also identified throughout the study period. Widespread vaccination may alter the RV seasonal pattern. The finding of RV disease affecting older children and adolescents after vaccine implementation has been reported worldwide. G2P[4] emergence most likely follows a global trend seemingly unrelated to vaccination, and G12, apparently, is emerging in the Brazilian population. The rapidly changing RV genotype patterns detected during this study illustrate a dynamic population of co-circulating wildtype RVs in Brazil.

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Published

2015-08-01

How to Cite

LUCHS, A., CILLI, A., MORILLO, S. G., CARMONA, R. de C. C., & TIMENETSKY, M. do C. S. T. (2015). ROTAVIRUS GENOTYPES CIRCULATING IN BRAZIL, 2007-2012: IMPLICATIONS FOR THE VACCINE PROGRAM . Revista Do Instituto De Medicina Tropical De São Paulo, 57(4), 305-313. Retrieved from https://www.revistas.usp.br/rimtsp/article/view/105541

Issue

Section

Virology