SERUM LEVELS OF COPPER AND IRON IN DENGUE FEVER

Authors

  • Rajendiran SOUNDRAVALLY Jawaharlal Institute of Postgraduate Medical Education and Research; Department of Biochemistry
  • Jacob SHERIN Jawaharlal Institute of Postgraduate Medical Education and Research; Department of Biochemistry
  • Balakrishna Pillai AGIESHKUMAR SASTRA University; School of Chemical and Biotechnology
  • Mariya Samadanam DAISY Jawaharlal Institute of Postgraduate Medical Education and Research; Department of Biochemistry
  • Cherupanakkal CLEETUS Jawaharlal Institute of Postgraduate Medical Education and Research; Department of Biochemistry
  • Parameswaran NARAYANAN Jawaharlal Institute of Postgraduate Medical Education and Research; Department of Pediatrics
  • Tamilarasu KADHIRAVAN Jawaharlal Institute of Postgraduate Medical Education and Research; Department of Medicine
  • Sistla SUJATHA Jawaharlal Institute of Postgraduate Medical Education and Research; Department of Microbiology
  • Kottyen Thazhath HARICHANDRAKUMAR Jawaharlal Institute of Postgraduate Medical Education and Research; Department of Statistics

Abstract

The role of trace elements in dengue virulence is not yet known. The present study assessed the serum levels of two micronutrients, copper and iron, in cases of dengue fever. The study involved 96 patients of whom 48 had either severe or non-severe forms of dengue (with and without warning signs), and the remaining 48 were patients with other febrile illnesses (OFI), used as controls. Serum levels of copper and iron were evaluated at admission and by the time of defervescence using commercially available kits. At admission, no difference in the level of serum copper was observed between cases and controls. In the group of dengue cases, the copper level was found to be significantly decreased in severe and non-severe cases with warning signs, compared to non-severe cases without warning signs. In contrast, by the time of defervescence the copper level was found to be increased in all dengue cases compared to OFI controls, but no difference was observed among dengue cases. Unlike OFI controls, dengue cases showed an increasing pattern of copper levels from admission until defervescence. On the other hand, no such significant differences were observed in the serum level of iron in the clinical groups, except for a decreased iron level found in severe cases, compared to non-severe dengue without warning signs. The results show that copper is associated with dengue severity and this finding emphasizes the need to investigate the involvement of trace elements in disease severity so as to improve the prognosis of dengue.

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Published

2015-08-01

How to Cite

SOUNDRAVALLY, R., SHERIN, J., AGIESHKUMAR, B. P., DAISY, M. S., CLEETUS, C., NARAYANAN, P., KADHIRAVAN, T., SUJATHA, S., & HARICHANDRAKUMAR, K. T. (2015). SERUM LEVELS OF COPPER AND IRON IN DENGUE FEVER. Revista Do Instituto De Medicina Tropical De São Paulo, 57(4), 315-320. Retrieved from https://www.revistas.usp.br/rimtsp/article/view/105542

Issue

Section

Virology