ANTIFUNGAL POTENTIAL OF PLANT SPECIES FROM BRAZILIAN CAATINGA AGAINST DERMATOPHYTES

Authors

  • Renata Perugini BIASI-GARBIN Universidade Estadual de Londrina; Centro de Ciências Biológicas; Departamento de Microbiologia
  • Fernanda de Oliveira DEMITTO Universidade Estadual de Maringá; Centro de Ciências Biológicas; Departamento de Análises Clínicas
  • Renata Claro Ribeiro do AMARAL Universidade Estadual de Maringá; Centro de Ciências Biológicas; Departamento de Análises Clínicas
  • Magda Rhayanny Assunção FERREIRA Universidade Federal de Pernambuco; Centro de Ciências da Saúde; Departamento de Farmácia
  • Luiz Alberto Lira SOARES Universidade Federal de Pernambuco; Centro de Ciências da Saúde; Departamento de Farmácia
  • Terezinha Inez Estivalet SVIDZINSKI Universidade Estadual de Maringá; Centro de Ciências Biológicas; Departamento de Análises Clínicas
  • Lilian Cristiane BAEZA Universidade Estadual de Maringá; Centro de Ciências Biológicas; Departamento de Análises Clínicas
  • Sueli Fumie YAMADA-OGATTA Universidade Estadual de Londrina; Centro de Ciências Biológicas; Departamento de Microbiologia

Abstract

Trichophyton rubrum and Trichophyton mentagrophytes complex, or Trichophyton spp. are the main etiologic agents of dermatophytosis, whose treatment is limited by the high cost of antifungal treatments, their various side effects, and the emergence of resistance amongst these species. This study evaluated the in vitro antidermatophytic activity of 23 crude extracts from nine plant species of semiarid vegetation (caatinga) found in Brazil. The extracts were tested at concentrations ranging from 1.95 to 1,000.0 mg/mL by broth microdilution assay against the reference strains T. rubrum ATCC 28189 and T. mentagrophytesATCC 11481, and 33 clinical isolates of dermatophytes. All plants showed a fungicidal effect against both fungal species, with MIC/MFC values of the active extracts ranging from 15.6 to 250.0 µg/mL. Selected extracts of Eugenia uniflora (AcE), Libidibia ferrea (AE), and Persea americana (AcE) also exhibited a fungicidal effect against all clinical isolates of T. rubrum and T. mentagrophytes complex. This is the first report of the antifungal activity of Schinus terebinthifolius, Piptadenia colubrina, Parapiptadenia rigida, Mimosa ophthalmocentra, and Persea americana against both dermatophyte species.

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Published

2016-01-01

Issue

Section

Original Articles

How to Cite

BIASI-GARBIN, R. P., DEMITTO, F. de O., AMARAL, R. C. R. do, FERREIRA, M. R. A., SOARES, L. A. L., SVIDZINSKI, T. I. E., BAEZA, L. C., & YAMADA-OGATTA, S. F. (2016). ANTIFUNGAL POTENTIAL OF PLANT SPECIES FROM BRAZILIAN CAATINGA AGAINST DERMATOPHYTES . Revista Do Instituto De Medicina Tropical De São Paulo, 58, e18-. https://www.revistas.usp.br/rimtsp/article/view/113161