The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites

Authors

  • H. Gomez-Banqueri Instituto Lopez-Neyra de Parasitologia C.S.I.C
  • M. A. Garcia Ruiz Instituto Lopez-Neyra de Parasitologia C.S.I.C
  • M. Monteoliva Instituto Lopez-Neyra de Parasitologia C.S.I.C
  • M. Sanchez-Moreno Instituto Lopez-Neyra de Parasitologia C.S.I.C

Keywords:

Glucógeno sintetasa - inhibicion, Parbendazol, Mebendazol, Albendazol, Tiabendaúol, Ascaris suum, Fasciola hepatica, Moniezia expansa

Abstract

The inhibitor effect on the Glycogen synthetase (E.C.2.4.1.11) activity by four anthelmintics: Mebendazole, Parbendazole, Albendazole and Thiabendazole was determinated. The most inhibitor effect of Parbendazole on A. suum, F. hepatica and M. expansa, was observed. The lowest inhibitor effect of Thiabendazole, on all cases, was also observed. The aim of our study, and further studies on the same line, are to provide new reports about the unknown locus of actuation of these anthelmintics.

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Published

1987-08-01

Issue

Vol. 29 No. 4 (1987)

Section

Original Articles

How to Cite

Gomez-Banqueri, H., Garcia Ruiz, M. A., Monteoliva, M., & Sanchez-Moreno, M. (1987). The inhibitor effect of Benzimidazoles in the glycogen synthetase of helminthics parasites . Revista Do Instituto De Medicina Tropical De São Paulo, 29(4), 200-204. https://www.revistas.usp.br/rimtsp/article/view/28519