Cytomegalovirus and other herpesviruses infections in heart and bone marrow transplant recipients

Authors

  • Adriana Weinberg University of São Paulo; Hospital das Clínicas; Division of Infectious Diseases
  • Lucy S. Vilas Boas Instituto de Medicina Tropical; Virology laboratory
  • Olavo Feher FMUSP; Hospital das Clínicas; Division of Hematology
  • Tania M. V. Strabelli Incor; FMUSP; HC; Infection Control Commitee of the Instituto do Coração
  • Maria Cristina D. S. Fink Instituto de Medicina Tropical; Virology laboratory
  • Frederico L. Dulley FMUSP; Hospital das Clínicas; Division of Hematology
  • David E. Uip Incor; FMUSP; HC; Infection Control Commitee of the Instituto do Coração
  • Giovani Bellotti Incor
  • Dalton A. F. Chamone FMUSP; Hospital das Clínicas; Division of Hematology
  • Vicente Amato Neto University of São Paulo; Hospital das Clínicas; Division of Infectious Diseases
  • Cláudio S. Pannuti Instituto de Medicina Tropical; Virology laboratory

Keywords:

Cytomegalovirus infection, Herpesviruses infection, Immunocompro-mised host, Transplantation

Abstract

From January 1988 to January 1989 all the heart transplant and bone marrow recipients at the Instituto do Coração of the Hospital das Clínicas of the University of São Paulo Medical School were studied for the incidence and morbidity associated with herpesviruses infections after transplantation. Five bone marrow and 5 heart transplant recipients were followed for a mean of 4.2 months post-transplantation. All the patients were seropositive for cytomegalovirus (CMV) before admission and 80% experienced one or more recurrences during the observation period. Of the 12 episodes of CMV infection, that were identified in this study, 83% were accompanied by clinical or laboratory abnormalities. However, there was only one case of severe disease. The overall incidence of infection for herpes simplex (HSV) was 50%. Although most of HSV reactivations were oral or genital, one case of HSV hepatitis occurred. One of the 6 episodes of HSV infections that were treated with acyclovir showed an unsatisfactory response and was successfully managed with ganciclovir. All the individuals had anti-varicella zoster virus antibodies, but none of them developed infection. The study emphasizes the importance of active diagnostic surveillance of herpesvirus infections in transplant patients. Both CMV and HSV reactivations showed high incidence and important morbidity and thus, deserve prophylactic therapy.

Downloads

Download data is not yet available.

Downloads

Published

1990-10-01

How to Cite

Weinberg, A., Vilas Boas, L. S., Feher, O., Strabelli, T. M. V., Fink, M. C. D. S., Dulley, F. L., Uip, D. E., Bellotti, G., Chamone, D. A. F., Amato Neto, V., & Pannuti, C. S. (1990). Cytomegalovirus and other herpesviruses infections in heart and bone marrow transplant recipients . Revista Do Instituto De Medicina Tropical De São Paulo, 32(5), 338-345. Retrieved from https://www.revistas.usp.br/rimtsp/article/view/28757

Issue

Section

Original Articles