Schistosoma mansoni: acquired immunity in mice after the use of oxamniquine at the evolutive skin and pulmonary phases
Keywords:
Schistosoma mansoni, Acquired immunity, OxamniquineAbstract
Mice infected with 350 cercariae of Schistosoma mansoni (LE strain) were treated with oxamniquine, at the dose of 400 mg/kg, 24, 48, 72, and 96 h after infection. Forty days after the treatment, the animals were submitted to a challenge infection with 80 cercariae, through the abdominal and ear skins. The number of immature worms in the animal groups treated 24 and 96 h after the first infection was found to be lower than that in the control group, thus showing that the death of schisto-somes by chemotherapy, at the skin and pulmonary phases, causes an acquired resistance state.Downloads
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Published
1991-02-01
Issue
Section
Immunology
How to Cite
Coelho, P. M. Z., Mello, R. T., & Gerken, S. E. (1991). Schistosoma mansoni: acquired immunity in mice after the use of oxamniquine at the evolutive skin and pulmonary phases . Revista Do Instituto De Medicina Tropical De São Paulo, 33(1), 28-31. https://www.revistas.usp.br/rimtsp/article/view/28788