Immunomodulatory effect of cimetidine on the proliferative responses of splenocytes from T. cruzi-infected rats

Authors

  • M.N. Sato Universidade de São Paulo; Faculdade de Medicina; Disciplina de Alergia e Imunopatologia; Laboratório de Imunogenética e Transplante Experimental
  • E.H. Yamashiro-Kanashiro Universidade de São Paulo; Faculdade de Medicina; Disciplina de Alergia e Imunopatologia; Laboratório de Imunogenética e Transplante Experimental
  • M.M. Tanji Universidade de São Paulo; Faculdade de Medicina; Disciplina de Alergia e Imunopatologia; Laboratório de Imunogenética e Transplante Experimental
  • R. Kaneno Universidade de São Paulo; Faculdade de Medicina; Disciplina de Alergia e Imunopatologia; Laboratório de Imunogenética e Transplante Experimental
  • R.Y. Iqueoka Universidade de São Paulo; Faculdade de Medicina; Disciplina de Alergia e Imunopatologia; Laboratório de Imunogenética e Transplante Experimental
  • A.J.S. Duarte Universidade de São Paulo; Faculdade de Medicina; Disciplina de Alergia e Imunopatologia; Laboratório de Imunogenética e Transplante Experimental

Keywords:

Trypanosoma cruzi, Rat, Inbred strain, Cimetidine, Immunoregulation

Abstract

The immunomodulatory effect of cimetidine (CIM), a histamine type-2 receptor antagonist, was evaluated in respect to the blastogenic response to Con A of Wistar Furth (WF) rats infected by the Y strain of Trypanosoma cruzi (T. cruzi). Enhancement of blastogenesis of normal splenocytes was observed at a concentration of 10-3M. However, the splenocytes from infected animals responded to concentrations of CIM ranging from 10-8 to 10-3M. The mitogenic response to Con A of cells from infected animals was restored in the presence of CIM. The results show that CIM modulates the "in vitro" proliferative response of cells from T. cruzi-infected rats and suggest an immunoregulatory role of histamine and/or of cells that express H2 receptors in this infection.

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Published

1991-06-01

Issue

Vol. 33 No. 3 (1991)

Section

Original Article

How to Cite

Sato, M., Yamashiro-Kanashiro, E., Tanji, M., Kaneno, R., Iqueoka, R., & Duarte, A. (1991). Immunomodulatory effect of cimetidine on the proliferative responses of splenocytes from T. cruzi-infected rats . Revista Do Instituto De Medicina Tropical De São Paulo, 33(3), 187-192. https://www.revistas.usp.br/rimtsp/article/view/28817