Neuronal counting and parasympathetic dysfunction in the hearts of chronically Trypanosoma cruzi - infected rats

Authors

  • E. Chapadeiro
  • R.F.C. Florêncio
  • P.C. Afonso
  • P.S.S. Beraldo
  • P.C. de Jesus
  • L.F. Junqueira Jr.

Keywords:

Cardiac parasympathetic dysfunction, Experimental Chagas' disease, Neuroganglionitis, T. cruzi, Neuronal counting

Abstract

Ten male Wistar rats, chronically infected with Colombian, São Felipe (12SF) and Y strains of Trypanosoma cruzi and ten non-infected control animals were submitted to the bradycardia responsiveness test, an assessment of heart parasympathetic function, after phenylephrine injection. Six chagasic animals showed heart parasympathetic dysfuntion characterized by reduction in the index of bradycardia baroreflex responsiveness, as compared with the control group. Microscopic examination of the atrial heart ganglia of chagasic rats showed ganglionitis, but no statiscally significant reduction in the number of neurons.

Downloads

Download data is not yet available.

Downloads

Published

1991-10-01

Issue

Vol. 33 No. 5 (1991)

Section

Original Article

How to Cite

Chapadeiro, E., Florêncio, R., Afonso, P., Beraldo, P., Jesus, P. de, & Junqueira Jr., L. (1991). Neuronal counting and parasympathetic dysfunction in the hearts of chronically Trypanosoma cruzi - infected rats . Revista Do Instituto De Medicina Tropical De São Paulo, 33(5), 337-341. https://www.revistas.usp.br/rimtsp/article/view/28851