Exposure to acellular blood products and risk of HIV infection in hemophiliacs from Belo Horizonte, Brazil

Authors

  • Fernando A. Proietti Johns Hopkins School of Hygiene and Public Health; Dep. of Epidemiology
  • Anna Barbara F. C. Proietti Fundação Hemominas
  • Maria Fernanda F. L. Costa Universidade Federal de Minas Gerais; Dep. Medicina Preventiva Social
  • Carlos M. F. Antunes Johns Hopkins School of Hygiene and Public Health; Dep. of Epidemiology
  • Mark D. C. Guimarães Johns Hopkins School of Hygiene and Public Health; Dep. of Epidemiology
  • Urquiza H. M. Paulino Universidade Federal de Minas Gerais
  • Caio J. C. Souza Fundação Hemominas
  • Laércio Melo Fundação Hemominas
  • Álvaro Munõz Johns Hopkins School of Hygiene and Public Health; Dep. of Epidemiology

Keywords:

Hemophiliacs, HIV, blood products, Brazil

Abstract

Results of a HIV prevalence study conducted in hemophiliacs from Belo Horizonte, Brazil are presented. History of exposure to acellular blood components was determined for the five year period prior to entry in the study, which occurred during 1986 and 1987. Patients with coagulations disorders (hemophilia A = 132, hemophilia B = 16 and coagulation disorders other than hemophilia = 16) were transfused with liquid cryoprecipitate, locally produced, lyophilized cryoprecipitate, imported from São Paulo (Brazil) and factor VIII and IX, imported from Rio de Janeiro (Brazil), Europe, and United States. Thirty six (22%) tested HIV seropositive. The univariate and multivariate analysis (logistic model) demonstrated that the risk of HIV infection during the study period was associated with the total units of acellular blood components transfused. In addition, the proportional contribution of the individual components to the total acellular units transfused, namely a increase in factor VIII/IX and lyophilized cryoprecipitate proportions, were found to be associated with HIV seropositivity. This analysis suggest that not only the total amount of units was an important determinant of HIV infection, but that the risk was also associated with the specific component of blood transfused

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Published

1992-06-01

Issue

Vol. 34 No. 3 (1992)

Section

Epidemiology

How to Cite

Proietti, F. A., Proietti, A. B. F. C., Costa, M. F. F. L., Antunes, C. M. F., Guimarães, M. D. C., Paulino, U. H. M., Souza, C. J. C., Melo, L., & Munõz, Álvaro. (1992). Exposure to acellular blood products and risk of HIV infection in hemophiliacs from Belo Horizonte, Brazil . Revista Do Instituto De Medicina Tropical De São Paulo, 34(3), 227-232. https://www.revistas.usp.br/rimtsp/article/view/28924