Snake envenomation in children: early reactions frequency at antivenom in patients pretreated with histamine antagonists HI and H2 and hydrocortisone

Authors

  • Fábio Bucarethi UNICAMP; FCM; Depto. de Pediatria
  • Joyce L. Douglas Universidade Estadual de Campinas; Faculdade de Ciências Médicas; Hospital das Clínicas; Centro de Controle de Intoxicações
  • Márcia R. C. C. Fonseca Universidade Estadual de Campinas; Faculdade de Ciências Médicas; Hospital das Clínicas; Centro de Controle de Intoxicações
  • Flávio A. D. Zambrone UNICAMP; FCM; Depto. de Medicina Preventiva
  • Ronan J. Vieira Universidade Estadual de Campinas; Faculdade de Ciências Médicas; Hospital das Clínicas; Centro de Controle de Intoxicações

Keywords:

Acidentes ofídicos, Antiveneno, Reações precoces

Abstract

Type and frequency of early reactions (ER) were studied in 24 children aging 2-14 years victims of snake bites who received pretreatment with histamine antagonists H1 (dextrochlorfenirarnine) and H2 (cimetidine or ranitidine) and hydrocortisone from 1989 to 1993. None of them had atopy nor received any type of anti-venoms(AV) and antitoxins before. Of 24 children, 15 received bothropic AV (ER in 5), 7 crotalic AV (ER in 5), 1 crotalic plus crotalic-bothropic AV, and 1 elapidic AV (ER in 1). In 3 children severe early reactions were observed and they were classified as severe crotalic accident. Results suggest that pre-treatment did not offer safety protection at the appearance of early reactions.

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Published

1994-10-01

Issue

Vol. 36 No. 5 (1994)

Section

Animal Venoms

How to Cite

Bucarethi, F., Douglas, J. L., Fonseca, M. R. C. C., Zambrone, F. A. D., & Vieira, R. J. (1994). Snake envenomation in children: early reactions frequency at antivenom in patients pretreated with histamine antagonists HI and H2 and hydrocortisone . Revista Do Instituto De Medicina Tropical De São Paulo, 36(5), 451-457. https://www.revistas.usp.br/rimtsp/article/view/29198