Long term follow-up and patterns of response of ALT in patients with chronic hepatitis NANB/C treated with recombinant interferon-alpha
Keywords:
Chronic hepatitis, Hepatitis C, Antiviral Therapy, Interferon, Response, RelapseAbstract
The response to interferon treatment in chronic hepatitis NANB/C has usually been classified as complete, partial or absent, according to the behavior of serum alanine aminotransferase (ALT). However, a more detailed observation of the enzymatic activity has shown that the patterns may be more complex. The aim of this study was to describe the long term follow-up and patterns of ALT response in patients with chronic hepatitis NANB/C treated with recombinant interferon-alpha. A follow-up of 6 months or more after interferon-a was achieved in 44 patients. We have classified the serum ALT responses into six patterns and the observed frequencies were as follows: I. Long term response = 9 (20.5%); II. Normalization followed by persistent relapse after IFN = 7 (15.9%); III. Normalization with transient relapse = 5 (11.9%); IV. Temporary normalization and relapse during IFN = 4 (9.1%); V. Partial response (more than 50% of ALT decrease) = 7 (15.9%); VI. No response = 12 (27.3%). In conclusion, ALT patterns vary widely during and after IFN treatment and can be classified in at least 6 types.Downloads
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Published
1995-06-01
Issue
Section
Clinical Studies
How to Cite
Silva, L. da, Ono, S., Fonseca, L., Carrilho, F., Mendes, L., França, A., Madruga, C., & Laudanna, A. (1995). Long term follow-up and patterns of response of ALT in patients with chronic hepatitis NANB/C treated with recombinant interferon-alpha . Revista Do Instituto De Medicina Tropical De São Paulo, 37(3), 239-243. https://www.revistas.usp.br/rimtsp/article/view/29268