Lethal effect of oxamniquine and praziquantel on mice experimentally infected with Schistosoma mansoni
Keywords:
Schistosoma mansoni, LD50, Oxamniquine, PraziquantelAbstract
Lethality caused by administration of oxamniquine and praziquantel to mice infected with Schistosoma mansoni, and their respective controls (uninfected), has been studied. As the results indicate, the infected animals clearly showed higher mortality rates when praziquantel was used. Surprisingly, it may be noted that exactly the contrary occurs in relation to the use of oxamniquine, inasmuch as marked higher mortality rates were seen in the control animals (uninfected). These observations lead to the conclusion that further toxicological studies of antischistosomal drugs using. S. mansoni infected animals are needed.Downloads
Download data is not yet available.
Downloads
Published
1995-08-01
Issue
Section
Brief Communication
How to Cite
Tonelli, S. M. A., Goulart, E. M., Tonelli, E., & Coelho, P. M. Z. (1995). Lethal effect of oxamniquine and praziquantel on mice experimentally infected with Schistosoma mansoni . Revista Do Instituto De Medicina Tropical De São Paulo, 37(4), 361-363. https://www.revistas.usp.br/rimtsp/article/view/29291