Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection: II. Corynebacterium parvum
Keywords:
Corynebacterium parvum, Schistosoma mansoni, Immunopotentiators, ChemotaxisAbstract
The effects of Corynebacterium parvum on host protection, tissue reaction and "in vivo" chemotaxis in Schistosoma mansoni infected mice were studied. The C. parvum was given intraperitoneally using a dose of 0.7 mg, twice a week (for 4 weeks), thirty days before (prophylactic treatment) or after infection (curative treatment). The host protection was evaluated through the recovery of adult worms by liver perfusion and was lower in the prophylactic group as compared to the control group (p = 0.018), resulting in 44% protection. The "in vivo" leukocyte response in both prophylactic and curative groups was higher as compared to the infected/non treated group (p = 0.009 and p = 0.003, respectively). Tissue reactions were described in the experimental and control groups, but there were not remarkable differences among them. The possible biological implications and relevance of the findings for the defensive response of the host and control of schistosomiasis are discussed.Downloads
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Published
1996-10-01
Issue
Section
Schistomiasis
How to Cite
Teixeira, K. M., Coutinho, E. M., Abath, F. G., & Montenegro, S. M. (1996). Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection: II. Corynebacterium parvum . Revista Do Instituto De Medicina Tropical De São Paulo, 38(5), 359-364. https://www.revistas.usp.br/rimtsp/article/view/29401