Assessment of the rapid test based on an immunochromatography technique for detecting anti-Treponema pallidum antibodies

Authors

  • Neuza Satomi Sato Instituto Adolfo Lutz; Seção de Sorologia
  • Carmen Silvia de Melo Instituto Adolfo Lutz; Seção de Sorologia
  • Lia C.M.S. Zerbini Instituto Adolfo Lutz; Seção de Sorologia
  • Edilene P.R. Silveira Instituto Adolfo Lutz; Seção de Sorologia
  • Luiz Jorge Fagundes Universidade de São Paulo; Faculdade de Saúde Pública; Centro de Saúde Geraldo de Paula Souza
  • Mirthes Ueda Instituto Adolfo Lutz; Serviço de Microbiologia e Imunologia

Keywords:

Syphilis, Treponema pallidum, Immunochromatography assay, Antibody, Rapid test

Abstract

A rapid test based on an immunochromatography assay - Determine™ Syphilis TP (Abbott Lab.) for detecting specific antibodies to Treponema pallidum was evaluated against serum samples from patients with clinical, epidemiological and serological diagnosis of syphilis, patients with sexually transmitted disease other than syphilis, and individuals with negative serology for syphilis. The Determine™ test presented the sensitivity of 93.6%, specificity of 92.5%, and positive predictive value and negative predictive value of 95.2% and 93.7%, respectively. One serum sample from patient with recent latent syphilis showed a prozone reaction. Determine™ is a rapid assay, highly specific and easy to perform. This technique obviates the need of equipment and its diagnostic features demonstrate that it may be applicable as an alternative assay for syphilis screening under some emergency conditions or for patients living in remote localities.

Downloads

Download data is not yet available.

Downloads

Published

2003-12-01

Issue

Section

Syphilis

How to Cite

Sato, N. S., Melo, C. S. de, Zerbini, L. C., Silveira, E. P., Fagundes, L. J., & Ueda, M. (2003). Assessment of the rapid test based on an immunochromatography technique for detecting anti-Treponema pallidum antibodies . Revista Do Instituto De Medicina Tropical De São Paulo, 45(6), 319-322. https://www.revistas.usp.br/rimtsp/article/view/30762