In vitro synergism of simvastatin and fluconazole against Candida species

Authors

  • Everardo Albuquerque Menezes Federal University of Ceará; College of Pharmacy; Department of Clinical Analysis and Toxicology; Laboratory of Microbiology of Yeasts
  • Antônio Alexandre de Vasconcelos Júnior Federal University of Ceará; College of Pharmacy; Department of Clinical Analysis and Toxicology; Laboratory of Microbiology of Yeasts
  • Carlla Lorena Façanha Silva Federal University of Ceará; Science Center
  • Fábio Ximenes Plutarco Federal University of Ceará; College of Pharmacy; Department of Clinical Analysis and Toxicology; Laboratory of Microbiology of Yeasts
  • Maria da Conceição dos Santos Oliveira Cunha Federal University of Ceará; College of Pharmacy; Department of Clinical Analysis and Toxicology; Laboratory of Microbiology of Yeasts
  • Francisco Afrânio Cunha Federal University of Ceará; College of Pharmacy; Department of Clinical Analysis and Toxicology; Laboratory of Microbiology of Yeasts

Keywords:

Simvastatin, Fluconazole, Candida spp

Abstract

Systemic fungal infections are responsible for high mortality rates. Several species of fungi may be involved, but Candida spp. is the most prevalent. Simvastatin is used to lower cholesterol and also exhibits antifungal action. The aim of this study was to evaluate the synergistic action of simvastatin with fluconazole against strains of Candida spp. Susceptibility testing was performed according to protocol M27-A3, by broth microdilution method and the synergistic effect of simvastatin and fluconazole was calculated based on FICI (Fractional Inhibitory Concentration Index). Eleven strains were evaluated, and simvastatin showed a synergistic effect with fluconazole against 10 (91%) of the Candida spp. strains tested. Simvastatin may be a valuable drug in the treatment of systemic infections caused by Candida spp.

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Published

2012-08-01

Issue

Vol. 54 No. 4 (2012)

Section

Mycology

How to Cite

Menezes, E. A., Vasconcelos Júnior, A. A. de, Silva, C. L. F., Plutarco, F. X., Cunha, M. da C. dos S. O., & Cunha, F. A. (2012). In vitro synergism of simvastatin and fluconazole against Candida species. Revista Do Instituto De Medicina Tropical De São Paulo, 54(4), 197-199. https://www.revistas.usp.br/rimtsp/article/view/48389