Evaluation of ketoconazole in the treatment of paracoccidioidomycosis

Authors

  • Jussara Marcondes UNESP; Faculdade de Medicina do Campus de Botucatu; Departamento de Moléstias Infecciosas e Parasitárias, Dermatologia e Radiologia
  • Domingos Alves Meira UNESP; Faculdade de Medicina do Campus de Botucatu; Departamento de Moléstias Infecciosas e Parasitárias, Dermatologia e Radiologia
  • Rinaldo Poncio Mendes UNESP; Faculdade de Medicina do Campus de Botucatu; Departamento de Moléstias Infecciosas e Parasitárias, Dermatologia e Radiologia
  • Paulo Camara Marques Pereira UNESP; Faculdade de Medicina do Campus de Botucatu; Departamento de Moléstias Infecciosas e Parasitárias, Dermatologia e Radiologia
  • Benedito Barraviera UNESP; Faculdade de Medicina do Campus de Botucatu; Departamento de Moléstias Infecciosas e Parasitárias, Dermatologia e Radiologia
  • Norma Gerusa da Silva Mota UNESP; Instituto Básico de Biologia Médica e Agrícola; Departamento de Microbiologia e Imunologia
  • José Morceli UNESP; Faculdade de Medicina do Campus de Botucatu; Departamento de Moléstias Infecciosas e Parasitárias, Dermatologia e Radiologia

Abstract

Twelve patients with chronical and sistemic lesions due to paracoccidioidomycosis were treated with Ketoconazole. The treatment lasted for 18 months and the Ketoconazole was ad ministered by oral route, in a once a day do sage of 400 mg during the first month and of 200 mg in the next 17 months. All patients were evaluated in the course of the treatment as well as for 135 days after the end of it, by means of clinical picture, chest X-Ray and serological tests. The immune response was observed in all patients before the treatment and in 4 of them at the end of it. Results showed that there was recrudescence in 5 patients and side effect was observed in only one patient (pruritus). The agar-gel difusion and the sedimentation rate were the laboratorial findings which paralleled the best the clinical picture.

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Published

1984-04-01

Issue

Vol. 26 No. 2 (1984)

Section

Therapeutic Assays

How to Cite

Marcondes, J., Meira, D. A., Mendes, R. P., Pereira, P. C. M., Barraviera, B., Mota, N. G. da S., & Morceli, J. (1984). Evaluation of ketoconazole in the treatment of paracoccidioidomycosis . Revista Do Instituto De Medicina Tropical De São Paulo, 26(2), 113-121. https://www.revistas.usp.br/rimtsp/article/view/87263