Immunogenetic factors associated with type 1 diabetes mellitus

Authors

  • Ana Paula Morais Fernandes Universidade de São Paulo; Escola de Enfermagem de Ribeirão Preto
  • Ana Emilia Pace Universidade de São Paulo; Escola de Enfermagem de Ribeirão Preto
  • Maria Lúcia Zanetti Universidade de São Paulo; Escola de Enfermagem de Ribeirão Preto
  • Milton Cesar Foss Universidade de São Paulo; Faculdade de Medicina de Ribeirão Preto
  • Eduardo Antonio Donadi Universidade de São Paulo; Faculdade de Medicina de Ribeirão Preto

DOI:

https://doi.org/10.1590/S0104-11692005000500020

Keywords:

type I diabetes mellitus, immunogenetics, nursing

Abstract

Type 1 diabetes mellitus has been considered an organ-specific autoimmune disease derived from the selective destruction of pancreatic beta cells. It presents a complex pathogenesis, involving the participation of several factors, including the immunogenetic susceptibility with strong association to histocompatibility genes (HLA), environmental events and autoimmune response with the presence of autoantibodies and/or autoreactive lymphocytes, culminating in metabolic abnormalities. In this study, the literature review describes mechanisms through which some factors cause susceptibility to its appearance and, additionally, prediction innovations regarding this disorder, which will certainly contribute to nursing care for patients with type 1 diabetes.

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Published

2005-10-01

Issue

Vol. 13 No. 5 (2005)

Section

Review Articles

License

RLAE’s authorship concept is based on the substantial contribution by each of the individuals listed as authors, mainly in terms of conceiving and planning the research project, collecting or analyzing and interpreting data, writing and critical review. Indication of authors’ names under the article title is limited to six. If more, authors are listed on the online submission form under Acknowledgements. The possibility of including more than six authors will only be examined on multicenter studies, considering the explanations presented by the authors.
Including names of authors whose contribution does not fit into the above criteria cannot be justified. Those names can be included in the Acknowledgements section.
 Authors are fully responsible for the concepts disseminated in their manuscripts, which do not necessarily reflect the editors’ and editorial board’s opinion.

 

How to Cite

Immunogenetic factors associated with type 1 diabetes mellitus. (2005). Revista Latino-Americana De Enfermagem, 13(5), 743-749. https://doi.org/10.1590/S0104-11692005000500020