Drug interactions of anti-microbial agents used in hematopoietic stem cell transplantation

Authors

  • Rosimeire Barbosa Fonseca Guastaldi Universidade Paulista
  • Silvia Regina Secoli Universidade de São Paulo; Escola de Enfermagem

DOI:

https://doi.org/10.1590/S0104-11692011000400015

Keywords:

Drug Interactions, Oncologic Nursing, Nursing Assessment

Abstract

This study analyzed potential drug interactions (PDIs) of antimicrobials used in patients of hematopoietic stem cell transplantation and identified associated factors. The sample consisted of 70 patients admitted to a hospital in São Paulo. The PDIs were analyzed through the consultation of the Drug Interactions Facts and Drug Interactions Handbook. Descriptive statistics and logistic regression were used. Half of the sample was exposed to 13 PDIs, which occurred with fluconazole (53.8%), ciprofloxacin (30.8%) and sulfamethoxazole-trimethoprim (15.4%). Most (92.3%) were of moderate severity, with good evidence (61.6%), early delayed effect (61.5%) and need to have their therapy monitored (76.9%). Patients with four or more medications (p<0.001), aged between 40-49 years of age (p <0.001), and being male (p<0.001) were associated with PDIs. A PDI may result in adverse outcomes, impacting patients' morbidity and mortality. Combination regimens can be safe, provided there is careful monitoring by professionals involved in care delivery.

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Published

2011-08-01

Issue

Vol. 19 No. 4 (2011)

Section

Editorial

License

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Including names of authors whose contribution does not fit into the above criteria cannot be justified. Those names can be included in the Acknowledgements section.
 Authors are fully responsible for the concepts disseminated in their manuscripts, which do not necessarily reflect the editors’ and editorial board’s opinion.

 

How to Cite

Drug interactions of anti-microbial agents used in hematopoietic stem cell transplantation . (2011). Revista Latino-Americana De Enfermagem, 19(4), 960-967. https://doi.org/10.1590/S0104-11692011000400015