Clinical and laboratory parameters in dapsone acute intoxication
DOI:
https://doi.org/10.1590/S0034-89102000000400013Keywords:
Dapsone^i1^spoison, Methemoglobinemia^i1^sbl, Cyanosis, Intoxication, acuteAbstract
OBJECTIVE: To determine the severity of dapsone (DDS) acute intoxication an uncommon medical event using clinical and laboratory parameters. METHODS: Two hundred and seventy four patients with acute DDS intoxication, aged 1 month to 50 years old, were studied and classified into four age groups. Clinical evaluation was assessed through a protocol and correlated with laboratory parameters. Spectrophotometric methods were used to analyze methemoglobinemia (MHbp) and dapsonemia (DDSp). RESULTS: The most prevalent clinical sign of intoxication was cyanosis, seen in 65.7% of the patients and in 100% of children less than 5 years of age. According to laboratory criteria, MHbp-related severe clinical intoxication was seen in 56.2% and DDSp-related occurred in 58% of the patients. Regarding DDSp, intoxication was considered severe when 20 tablets (100 mg each) were ingested, a median of 29 mug/ml. Regarding MHbp, intoxication was severe when 7.5 tablets were ingested, a median of 38% of the total Hb. The correlation between MHbp and DDSp was statistically significant (n=144, r=0.32, p<0.05). Negative correlation was observed between MHbp and the time elapsed since DDS intake (n=124, r=-0.34, p<0.001). There was also a negative correlation between DDSp and the time elapsed since DDS intake (n=63, r=-0.35, p<0.0001). CONCLUSIONS: Longitudinal analysis showed a significant association between methemoglobinemia and the time elapsed after the intake (t), according to the equation: Dapsonemia = 12.9256 - 0.0682t + 0.234 methemoglobinemiaDownloads
Published
2000-08-01
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Original Articles
How to Cite
Carrazza, M. Z. N., Carrazza, F. R., & Oga, S. (2000). Clinical and laboratory parameters in dapsone acute intoxication . Revista De Saúde Pública, 34(4), 396-401. https://doi.org/10.1590/S0034-89102000000400013