Acquired hemophilia A in a patient with advanced prostate cancer

  • Daniel da Motta Girardi Clinical Oncology Department - Instituto do Câncer do Estado de São Paulo, São Paulo/SP
  • Douglas Rafael Almeida Silva Hospital das Clinicas - Faculdade de Medicina - Universidade de São Paulo, São Paulo/SP
  • Paula Ribeiro Villaça Hospital das Clinicas - Faculdade de Medicina - Universidade de São Paulo, São Paulo/SP
  • Ciro Eduardo Souza Clinical Oncology Department - Instituto do Câncer do Estado de São Paulo, São Paulo/SP
  • Leonardo Gomes da Fonseca Clinical Oncology Department - Instituto do Câncer do Estado de São Paulo, São Paulo/SP
  • Diogo Assed Bastos Clinical Oncology Department - Instituto do Câncer do Estado de São Paulo, São Paulo/SP
  • Paulo Marcelo Gehm Hoff Clinical Oncology Department - Instituto do Câncer do Estado de São Paulo, São Paulo/SP
Keywords: Factor 8 deficiency, acquired, Prostatic Neoplasm, Hemorrhage

Abstract

Acquired hemophilia A (AHA) is a rare disorder that results from the presence of autoantibodies against the clotting factor VIII (FVIII) causing hemorrhagic disorders. This entity is mostly associated with autoimmune diseases, pregnancy, the postpartum period, drugs and malignancy. Among the solid cancers, prostate neoplasm is the most common cause of AHA. The management of AHA involves the control of active bleeding and the use of specific therapies to eliminate the inhibitor. The authors describe the case of an 87-year-old man with prostate cancer who developed a bleeding disorder 5 years after the cancer diagnosis. Treatment with prednisone did not reach a satisfactory clinical response, which was only achieved with the association of azathioprine. The patient became asymptomatic with no further bleeding episodes, but developed a fatal sepsis after 3 months of treatment with these immunosuppressive agents.

Downloads

Download data is not yet available.
Published
2015-06-30
How to Cite
Girardi, D., Silva, D., Villaça, P., Souza, C., Fonseca, L., Bastos, D., & Hoff, P. (2015). Acquired hemophilia A in a patient with advanced prostate cancer. Autopsy and Case Reports, 5(2), 55-59. Retrieved from https://www.revistas.usp.br/autopsy/article/view/107006
Section
Article / Clinical Case Report