Evaluation of the efficacy of hyperimmune bovine colostrum on Cryptosporidium parvum experimental infection of rodents

Authors

  • Vicente José Salles de Abreu Universidade de São Paulo, Faculdade de Medicina, Instituto da Criança ‘Pedro de Alcântara’, São Paulo, SP
  • Ary Lopes Cardoso Universidade de São Paulo, Faculdade de Medicina, Instituto da Criança ‘Pedro de Alcântara’, São Paulo, SP
  • Hilda Fátima de Jesus Pena Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Medicina Veterinária Preventiva e Saúde Animal, São Paulo, SP
  • Solange Maria Gennari Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Medicina Veterinária Preventiva e Saúde Animal, São Paulo, SP
  • Idércio Sinhorini Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, São Paulo, SP
  • Sueli Blanes Damy Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Centro de Bioterismo, São Paulo, SP

DOI:

https://doi.org/10.1590/S1413-95962003000900006

Keywords:

Colostrum, Diseases animal models, Cryptosporidium parvum, Rodents, F344 endogamic rats

Abstract

The hyperimmune bovine colostrum has a high concentration of antibodies anti-Cryptosporidium parvum. This product is considered one of the promising therapeutic strategies in the control of intestinal cryptosporidiosis in humans. With the purpose to evaluate the hyperimmune bovine colostrum efficacy in reducing the parasitism and preventing intestinal mucosa alterations, several strains of rats F344 and mice were experimentally infected with Cryptosporidium parvum oocysts. The results showed that the hyperimmune bovine colostrum had high levels of antibodies. The rats F344, treated either with hyperimmune or normal bovine colostrum, had reduction of the intestinal parasitism and presented little mucosa compromise. The mice C57BL/6 when treated either with hyperimmune or normal colostrum had slight reduction of the intestinal parasitism and evidenced no statistical significant differences in the histopathological mucosa changes. In conclusion, the use of hyperimmune bovine colostrum has a limited benefit in Cryptosporidium parvum infection.

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Published

2003-01-01

How to Cite

Abreu, V. J. S. de, Cardoso, A. L., Pena, H. F. de J., Gennari, S. M., Sinhorini, I., & Damy, S. B. (2003). Evaluation of the efficacy of hyperimmune bovine colostrum on Cryptosporidium parvum experimental infection of rodents. Brazilian Journal of Veterinary Research and Animal Science, 40(supl.), 191-198. https://doi.org/10.1590/S1413-95962003000900006

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