Splenic congestion associated with acepromazine administration in dogs

Authors

  • Denise Cláudia Tavares Universidade Estadual Paulista "Júlio de Mesquita Filho", Faculdade de Ciências Agrárias e Veterinárias, Departamento de Medicina Veterinária Preventiva e Reprodução, Jaboticabal – SP, Brazil
  • Fabiana Ferreira Souza Universidade Estadual Paulista "Júlio de Mesquita Filho", Faculdade de Medicina Veterinária e Zootecnia, Departamento de Reprodução Animal e Radiologia Veterinária, Botucatu – SP, Brazil
  • Claudio Galvão Olivaes Universidade de Franca, Franca – SP, Brazil
  • Valeska Rodrigues Universidade de Franca, Franca – SP, Brazil
  • Thais Melo de Paula Seixas Universidade de Franca, Franca – SP, Brazil
  • Ewaldo de Mattos Junior Universidade de Franca, Franca – SP, Brazil
  • Gilson Hélio Toniollo Universidade Estadual Paulista "Júlio de Mesquita Filho", Faculdade de Ciências Agrárias e Veterinárias, Departamento de Medicina Veterinária Preventiva e Reprodução, Jaboticabal – SP, Brazil

DOI:

https://doi.org/10.11606/issn.1678-4456.v51i4p304-308

Keywords:

Canis lupus familiaris, Phenotiazines, Splenomegaly

Abstract

The aim of this study was evaluate splenic dilatation induced by acepromazine in a prospective, randomized study. Thirty-three adult mongrel dog were divided into two groups designated as AG (acepromazine 0.05 mg/kg, i.v., n = 23) and CG (0.9% sodium chloride administered at a similar volume, n = 10). In both groups underwent sonographic examinations before (T0) and fifteen minutes (T15) after drug injection. The thickness spleen and splenic vein width were measured. Higher thickness was found in the AG group at T15 (2.47 cm) when compared to that at T0 (2.06 cm, p = 0.016), while the T0 (2.33 cm) and T15 (2.39 cm) measures did not differ within the CG group. Moreover, the splenic vein width was higher (p = 0.013) at T15 than at T0 in the AG group. Based on results of this study, we concluded that acepromazine, in doses of 0.05 mg/kg, promotes splenomegaly in dogs after fifteen minutes of the injection.

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Published

2015-02-06

How to Cite

Tavares, D. C., Souza, F. F., Olivaes, C. G., Rodrigues, V., Seixas, T. M. de P., Mattos Junior, E. de, & Toniollo, G. H. (2015). Splenic congestion associated with acepromazine administration in dogs. Brazilian Journal of Veterinary Research and Animal Science, 51(4), 304-308. https://doi.org/10.11606/issn.1678-4456.v51i4p304-308

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