mpact of imabalance intestinal microbiota in the development of obesity
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2023.204198Keywords:
Dysbiosis, Obesity, Gastrointestinal microbiomeAbstract
OBJECTIVES: to review current database to identify the impacts of intestinal dysbiosis in obesity, besides being a role model to preventive measures, diagnosis and treatment. METHODOLOGY: this is an integrative review carried out from the collection of data obtained from the SciELO, PubMed, BVS and LILACS platforms using the descriptors “dysbiosis”, “obesity” and “gastrointestinal microbiome. Inclusion criteria were: articles published in the last 5 years (from 2017 to 2022), original articles, meta-analyses and observational studies (clinical trials and cohort study) and written in Portuguese, English or Spanish. RESULTS: occidental diet and the use of sweetener provoke alterations in anthropometric measures, blood pressure, glucose intolerance, and others, beyond increase of deleterious bacteria, causing obesity and diabetes; on the contrary, diets rich in fibers and probiotics lead to benefit changes in the diversity of intestinal microbiota, in addition to decrease inflammatory state caused by obesity.
Downloads
References
Informações sobre doenças – Sociedade Brasileira de Endocrinologia e Metabologia – Regional São Paulo. [Internet]. [cited 2022 Oct 25]. Available from: https://www.sbemsp.org.br/informacoes-sobre-doencas/
BRASILEIRO FILHO, G. Bogliolo - Patologia. 9. ed. Rio de Janeiro: Gen, Guanabara Koogan, 2016.
Um em cada quatro adultos do país estava obeso em 2019; Atenção Primária foi bem avaliada [Internet]. agenciadenoticias.ibge.gov.br. Available from: https://agenciadenoticias.ibge.gov.br/agencia-noticias/2012-agencia-de-noticias/noticias/29204-um-em-cada-quatro-adultos-do-pais-estava-obeso-em-2019
Classificação do diabetes [Internet]. Diretriz da Sociedade Brasileira de Diabetes. 2021. Available from: https://diretriz.diabetes.org.br/classificacao-do-diabetes/
Amabebe E, Robert FO, Agbalalah T, Orubu ESF. Microbial dysbiosis-induced obesity: role of gut microbiota in homoeostasis of energy metabolism. British Journal of Nutrition. 2020 Feb 3;123(10):1–11. Available from: https://www.cambridge.org/core/services/aop-cambridge-core/content/view/5EC03DE6BCDF529AD2E462E186FED193/S0007114520000380a.pdf/microbial-dysbiosis-induced-obesity-role-of-gut-microbiota-in-homoeostasis-of-energy-metabolism.pdf doi:10.1017/S0007114520000380
Reiter M, Krebs C, Lopes B, Nichelatti B, Moeller F, Screpec I. Microbiota Intestinal e sua Relação com a Alimentação. International Journal of Nutrology. 2018 Sep. Available from: Thieme E-Journals - International Journal of Nutrology / Full Text (thieme-connect.com) DOI: 10.1055/s-0038-1674833
Davis SC, Yadav JS, Barrow SD, Robertson BK. Gut microbiome diversity influenced more by the Westernized dietary regime than the body mass index as assessed using effect size statistic. MicrobiologyOpen. 2017 Jul 4;6(4):e00476. Available from: https://pubmed.ncbi.nlm.nih.gov/28677210/ DOI: 10.1002/mbo3.476
Zhao L, Zhang F, Ding X, Wu G, Lam YY, Wang X, et al. Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Science. 2018 Mar 8;359(6380):1151–6. Available from: https://www.science.org/doi/10.1126/science.aao5774 DOI: 10.1126/science.aao5774
Ojo O, Feng Q-Q, Ojo OO, Wang X-H. The Role of Dietary Fibre in Modulating Gut Microbiota Dysbiosis in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Nutrients. 2020 Oct 23;12(11):3239. Available from: https://pubmed.ncbi.nlm.nih.gov/33113929/ DOI: 10.3390/nu12113239
Farup PG, Lydersen S, Valeur J. Are Nonnutritive Sweeteners Obesogenic? Associations between Diet, Faecal Microbiota, and Short-Chain Fatty Acids in Morbidly Obese Subjects. Journal of Obesity. 2019 Oct 1;2019:1–8. Available from: https://pubmed.ncbi.nlm.nih.gov/31662903/ DOI: 10.1155/2019/4608315
de la Cuesta-Zuluaga J, Corrales-Agudelo V, Velásquez-Mejía EP, Carmona JA, Abad JM, Escobar JS. Gut microbiota is associated with obesity and cardiometabolic disease in a population in the midst of Westernization. Scientific Reports. 2018 Jul 27;8(1). Available from: https://www.nature.com/articles/s41598-018-29687-x DOI:10.1038/s41598-018-29687-x
Hermes GDA, Reijnders D, Kootte RS, Goossens GH, Smidt H, Nieuwdorp M, et al. Individual and cohort-specific gut microbiota patterns associated with tissue-specific insulin sensitivity in overweight and obese males. Scientific Reports. 2020 May 5;10(1). Available from: https://pubmed.ncbi.nlm.nih.gov/32371932/ DOI: 10.1038/s41598-020-64574-4
Ejtahed H-S, Soroush A-R, Siadat S-D, Hoseini-Tavassol Z, Larijani B, Hasani-Ranjbar S. Targeting obesity management through gut microbiota modulation by herbal products: A systematic review. Complementary Therapies in Medicine. 2019 Feb;42:184–204. Available from: https://pubmed.ncbi.nlm.nih.gov/30670241/ DOI: 10.1016/j.ctim.2018.11.019
Forbes JD, Azad MB, Vehling L, Tun HM, Konya TB, Guttman DS, et al. Association of Exposure to Formula in the Hospital and Subsequent Infant Feeding Practices With Gut Microbiota and Risk of Overweight in the First Year of Life. JAMA Pediatrics. 2018 Jul 2;172(7):e181161. Available from: https://pubmed.ncbi.nlm.nih.gov/29868719/ DOI: 10.1001/jamapediatrics.2018.1161
Guo Y, Luo S, Ye Y, Yin S, Fan J, Xia M. Intermittent Fasting Improves Cardiometabolic Risk Factors and Alters Gut Microbiota in Metabolic Syndrome Patients. The Journal of Clinical Endocrinology & Metabolism. 2020 Oct 6;106(1). Available from: https://pubmed.ncbi.nlm.nih.gov/33017844/ DOI: 10.1210/clinem/dgaa644
Joseph N, Clayton JB, Hoops SL, Linhardt CA, Mohd Hashim A, Mohd Yusof BN, et al. Alteration of the Gut Microbiome in Normal and Overweight School Children from Selangor with Lactobacillus Fermented Milk Administration. Evolutionary Bioinformatics. 2020 Jan;16:117693432096594. Available from: Alteration of the Gut Microbiome in Normal and Overweight School Children from Selangor with Lactobacillus Fermented Milk Administration | Article Information | J-GLOBAL (jst.go.jp) DOI: 10.1177/1176934320965943
Nogacka AM, Salazar N, Arboleya S, Ruas-Madiedo P, Mancabelli L, Suarez A, et al. In Vitro Evaluation of Different Prebiotics on the Modulation of Gut Microbiota Composition and Function in Morbid Obese and Normal-Weight Subjects. International Journal of Molecular Sciences. 2020 Jan 30;21(3):906. Available from: https://www.mdpi.com/1422-0067/21/3/906 DOI: 10.3390/ijms21030906
López-Moreno A, Suárez A, Avanzi C, Monteoliva-Sánchez M, Aguilera M. Probiotic Strains and Intervention Total Doses for Modulating Obesity-Related Microbiota Dysbiosis: A Systematic Review and Meta-analysis. Nutrients. 2020 Jun 29;12(7):1921. Available from: https://www.mdpi.com/2072-6643/12/7/1921/htm DOI: 10.3390/nu12071921
Janczy A, Aleksandrowicz-Wrona E, Kochan Z, Małgorzewicz S. Impact of diet and synbiotics on selected gut bacteria and intestinal permeability in individuals with excess body weight – A Prospective, Randomized Study. Acta Biochimica Polonica. 2020 Dec 16. Available from: https://ojs.ptbioch.edu.pl/index.php/abp/article/view/5443/4750 DOI: 10.18388/abp.2020_5443
Horvath A, Leber B, Feldbacher N, Tripolt N, Rainer F, Blesl A, et al. Effects of a multispecies synbiotic on glucose metabolism, lipid marker, gut microbiome composition, gut permeability, and quality of life in diabesity: a randomized, double-blind, placebo-controlled pilot study. European Journal of Nutrition. 2019 Nov 15;59(7):2969–83. Available from: https://link.springer.com/article/10.1007/s00394-019-02135-w DOI: 10.1007/s00394-019-02135-w
Kassaian N, Aminorroaya A, Feizi A, Jafari P, Amini M. The effects of probiotic and synbiotic supplementation on metabolic syndrome indices in adults at risk of type 2 diabetes: study protocol for a randomized controlled trial. Trials. 2017 Mar 29;18(1). Available from: https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-017-1885-8 DOI: 10.1186/s13063-017-1885-8
Wilkins LJ, Monga M, Miller AW. Defining Dysbiosis for a Cluster of Chronic Diseases. Scientific Reports [Internet]. 2019 Sep 9;9(1):1–10. Available from: https://www.nature.com/articles/s41598-019-49452-y DOI: 10.1186/s13063-017-1885-8
Cancello R, Turroni S, Rampelli S, Cattaldo S, Candela M, Cattani L, et al. Effect of Short-Term Dietary Intervention and Probiotic Mix Supplementation on the Gut Microbiota of Elderly Obese Women. Nutrients. 2019 Dec 10;11(12):3011. Available from: https://www.mdpi.com/2072-6643/11/12/3011/htm DOI: 10.3390/nu11123011
Nardelli C, Granata I, D’Argenio V, Tramontano S, Compare D, Guarracino MR, et al. Characterization of the Duodenal Mucosal Microbiome in Obese Adult Subjects by 16S rRNA Sequencing. Microorganisms. 2020 Mar 29;8(4):485. Available from: https://www.mdpi.com/2076-2607/8/4/485/htm DOI: 10.3390/microorganisms8040485
25- Barczynska R, Litwin M, Slizewska K, Szalecki M, Berdowska A, Bandurska K, et al. Bacterial Microbiota and Fatty Acids in the Faeces of Overweight and Obese Children. Polish Journal of Microbiology [Internet]. 2018 Sep 1 [cited 2022 Apr 24];67(3):339–45. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256813/ DOI: 10.21307/pjm-2018-041
Carrera-Quintanar L, Ortuño-Sahagún D, Franco-Arroyo N, Viveros-Paredes J, Zepeda-Morales A, Lopez-Roa R. The Human Microbiota and Obesity: A Literature Systematic Review of In Vivo Models and Technical Approaches. International Journal of Molecular Sciences. 2018 Nov 30;19(12):3827. Available from: https://www.mdpi.com/1422-0067/19/12/3827/htm DOI: 10.3390/ijms19123827
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Anna Laura Gomes Goulart, Ester Maria de Almeida Costa, Mariana Guedes Lopes Bacelar, Sâmya Silveira Nascimento, Thaynara Faria Gomes
This work is licensed under a Creative Commons Attribution 4.0 International License.
