Glutamatergic neurotransmission and synaptic plasticity: molecular, clinical, and phylogenetic aspects
DOI:
https://doi.org/10.11606/issn.2176-7262.v44i2p143-156Keywords:
Glutamate. Excitotoxicity. N-Methyl-D-Aspartate. Synaptic Plasticity. Neuroprotection.Abstract
Communication between neurons is subject to constant changes, even in the adult brain. This ability ofneural circuits to strengthen or weaken their specific synaptic interactions (a phenomenon known assynaptic plasticity) may occur according to different environmental demands, which favors the idea thatdynamic changes in the communication between neurons underlie behavioral flexibility (i.e., learningand memory processes). In recent decades, advances in neuroscience has allowed a better understanding of synaptic plasticity, specially the plasticity of glutamatergic synapses, whose molecular processes of synaptic change appear to be among the most common throughout the central nervous system.Much of this progress in basic science has contributed to a better understanding of pathological processes involving the glutamatergic synapses, such as Alzheimer's disease. Furthermore, the growingunderstanding about the physiology of glutamatergic communication has helped explain how synapses,in general, would have originated and evolved in the phylogenetic scale of the Metazoa. This reviewattempts to address clinical aspects of glutamatergic neurotransmission, coDownloads
Download data is not yet available.
Downloads
Published
2011-06-30
Issue
Section
Review
License
How to Cite
1.
Ruggiero RN, Bueno-Júnior LS, Ross JB de, Fachim HA, Padovan-Neto FE, Merlo S, et al. Glutamatergic neurotransmission and synaptic plasticity: molecular, clinical, and phylogenetic aspects. Medicina (Ribeirão Preto) [Internet]. 2011 Jun. 30 [cited 2024 May 16];44(2):143-56. Available from: https://www.revistas.usp.br/rmrp/article/view/47348