Effects of topical application of pure and ozonized andiroba oil on experimentally induced wounds in horses


  • Anderson Luiz Araujo UFBA
  • Fernanda Almeida Teixeira UVV-ES
  • Tracy Ferreira Lacerda UVV-ES
  • Mayra Cunha Flecher UVV-ES
  • Vinicius Ricardo Cuña Souza Veterinário autônomo
  • Clarisse Simões Coelho UVV-ES




Carapa guianensis, healing process, equines, wounds, ozone


The aim of this study was to evaluate clinical and histopathological aspects of topical application of pure and ozonized andiroba oil (Carapa guianensis Aublet.) on the healing process of wounds of healthy horses. Eight 6.25-cm2 wounds were surgically produced on each horse, cranial to the sacrum, being four wounds on each side of the lumbar region. In three animals, left side was used for macroscopic observations and area measurement and right side was used for histopathological analysis. For the other two animals, evaluations were inverted. Beginning of the topical treatment occurred 12 hours after surgical induction of the injuries and was maintained daily until complete healing of the wounds, using sequentially and bilaterally in the craniocaudal direction saline solution (GC), ozonized saline solution (GO), pure andiroba oil (GAP) and ozonized andiroba oil (GAO). Randomly, sequence of the treatments was modified. Macroscopic and histopathological analyses were performed at 3, 7, 14, and 21 days after surgery. Completed healing time for all wounds were recorded. A wound contraction of 67.75% for GC, 65.26% for GO, 67.91% for GAP, and 69.84% for GAO were recorded. Histopathologic evaluation revealed that wounds from the GAO and GAP had an advanced epithelialization, fibroblast proliferation and collagen deposition, moderate vascular proliferation, and presence of PMN infiltrate and discrete viewing of MN. It was possible to conclude that all treatments had benefits when comparing to control group and both pure and ozonized andiroba oil can be good options for wound treatment in horses.


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How to Cite

Araujo AL, Teixeira FA, Lacerda TF, Flecher MC, Souza VRC, Coelho CS. Effects of topical application of pure and ozonized andiroba oil on experimentally induced wounds in horses. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2017 May 19 [cited 2024 Apr. 15];54(1):66-74. Available from: https://www.revistas.usp.br/bjvras/article/view/113776