Evaluation of kidney injury through early markers in canine pyometra


  • Andrezza Cavalcanti de Andrade Universidade Federal de Alagoas, Departamento de Medicina Veterinária https://orcid.org/0000-0002-7067-3855
  • Érica Pereira da Silva Centro de Diagnóstico Veterinário
  • Joana D'Arc dos Santos Centro de Diagnóstico Veterinário
  • Karina Pessoa Oliveira Universidade Federal de Alagoas, Departamento de Medicina Veterinária
  • Karla Patrícia Chaves da Silva Universidade Federal de Alagoas, Departamento de Medicina Veterinária
  • Márcia Kikuyo Notomi Universidade Federal de Alagoas, Departamento de Medicina Veterinária




Symmetric dimethylarginine, Urinary gamma-glutamyl transferase, Acute kidney injury, Reproductive disorder


Fourteen female dogs diagnosed with pyometra were studied at three separate times: at diagnosis (T0) and 24 h (T1) and 10-15 days (T2) after ovariohysterectomy (OH). The means of the markers, symmetric dimethylarginine (SDMA) (17.71 to 26.54 μg/dL) and the urinary gamma-glutamyl transferase to creatinine ratio (uGGT/uCr) (1.06 to 2.62 U/mg), varied, showing an increase with time. Further, the elevation of gamma-glutamyl transferase (uGGT) (56.61 to 128.12 U/L) and the urinary protein to creatinine ratio (RPC) (0.26 to 1.24) was evident at T0 and T1. A reduction in the means of RPC, uGGT, and uGGT/uCr was observed 10-15 days after OH. Despite the elevation of these markers, the concentration of creatinine (1.11 to 1.40 mg/dL), urea (40.07 to 67.16 mg/dL), and urinary specific gravity (1.027 to 1.028) only presented slight variation. In canine pyometra, complications secondary to acute renal injury may be present that may be mild and transient in most treated animals. As elevation in SDMA and RPC preceded changes in creatinine levels for the evaluation of glomerular filtration, tubular markers could assist in the early identification of renal damage in canine pyometra. 


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Andrade AC de, Silva Érica P da, Santos JD dos, Oliveira KP, Silva KPC da, Notomi MK. Evaluation of kidney injury through early markers in canine pyometra. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2023 May 15 [cited 2024 Jul. 19];60:e199954. Available from: https://www.revistas.usp.br/bjvras/article/view/199954