Study of the variation in the serum concentrations of phenobarbital in dogs exposured to a long term treatment

Authors

  • Helena Arantes do Amaral Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Clínica Médica, São Paulo, SP
  • Maria Helena Matiko Akao Larsson Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Clínica Médica, São Paulo, SP

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.2006.26457

Keywords:

Phenobarbital, Serum concentration, Monitoring serum, Dog, Epilepsy

Abstract

In order to evaluate daily changes of concentration of phenobarbital during the interval of 12 hours of its administration, serum phenobarbital concentration were measured each two hours in 30 dogs submitted to the referred drug therapy for at least one month. All serum phenobarbital drug concentration were determined by use of a fluorecence polarization immunoassay. The values of half-lives obtained varied from 13 to 131 hours, most dogs reached steaty state serum concentrations by 15 days, and all dogs after four weeks. Therefore, clinicians should monitor serum phenobarbital concentrations four weeks after initiating treatment or after a change in dosage. There was significant difference among the averages of the samples two and four hours (peak) with the ones samples colected immediately before, and eight, 10 and 12 hours after its administration. In order to monitore serum phenobarbital concentrarions, its is suggest that blood collection is measured just before the dose or at any time between eight and 12 hours after its administration. If a concern arises regarding toxicity, a second sample should be colleted between two and four hours after phenobarbital administration.

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Published

2006-08-01

How to Cite

Amaral, H. A. do, & Larsson, M. H. M. A. (2006). Study of the variation in the serum concentrations of phenobarbital in dogs exposured to a long term treatment. Brazilian Journal of Veterinary Research and Animal Science, 43(4), 435-441. https://doi.org/10.11606/issn.1678-4456.bjvras.2006.26457

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