Evaluation of caspase-3 and Ki-67 as a prognostic markers in canine mammary tumors

Authors

  • Ana Carolina Bernardes Terzian Faculdade de Medicina de São José do Rio Preto, Departamento de Doenças Infecciosas e Parasitárias, Laboratório de Pesquisa em Virologia, São José do Rio Preto, SP
  • Debora Aparecida Pires de Campos Zuccari Centro Universitário de Rio Preto, São José do Rio Preto, SP
  • Rodrigo Storti Pereira Centro Universitário de Rio Preto, São José do Rio Preto, SP
  • Marcília Viana Pavam Centro Universitário de Rio Preto, São José do Rio Preto, SP
  • Camila Montanari Ruiz Centro Universitário de Rio Preto, São José do Rio Preto, SP
  • Felipe Augusto Ruiz Sueiro Centro Universitário de Rio Preto, São José do Rio Preto, SP
  • Joanna Coelho

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.2007.26647

Keywords:

Mammary tumors, Bitch, Immunohistochemical, Apoptosis, Cellular proliferation

Abstract

Apoptosis, as a cellular event, has an important participation in tumorigenesis, determining the tumoral growth and aggressiveness. The present study had as objective to evaluate the occurrence of apoptosis, associated cellular proliferation, in canine mammary neoplasias and the patient clinical evolution. Seventy dogs had been submitted to surgical excision of the tumor fragment and they were submitted to the histopathologic diagnosis and imunohistochemistry procedure to caspase-3 and the Ki-67. This apoptosis and cellular proliferation markers demonstrated great expression in malignant neoplasias especially carcinoma, considered the most malignant of the tumors. These results confirm consulted literature contributing for a criterious tumoral prognostic complementing the tumoral classification, providing a greater and better supervened due to adequacy of therapeutic procedure of each patient.

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Published

2007-04-01

How to Cite

Terzian, A. C. B., Zuccari, D. A. P. de C., Pereira, R. S., Pavam, M. V., Ruiz, C. M., Sueiro, F. A. R., & Coelho, J. (2007). Evaluation of caspase-3 and Ki-67 as a prognostic markers in canine mammary tumors. Brazilian Journal of Veterinary Research and Animal Science, 44(2), 96-102. https://doi.org/10.11606/issn.1678-4456.bjvras.2007.26647

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