Evaluation of caspase-3 and Ki-67 as a prognostic markers in canine mammary tumors
Keywords:Mammary tumors, Bitch, Immunohistochemical, Apoptosis, Cellular proliferation
AbstractApoptosis, as a cellular event, has an important participation in tumorigenesis, determining the tumoral growth and aggressiveness. The present study had as objective to evaluate the occurrence of apoptosis, associated cellular proliferation, in canine mammary neoplasias and the patient clinical evolution. Seventy dogs had been submitted to surgical excision of the tumor fragment and they were submitted to the histopathologic diagnosis and imunohistochemistry procedure to caspase-3 and the Ki-67. This apoptosis and cellular proliferation markers demonstrated great expression in malignant neoplasias especially carcinoma, considered the most malignant of the tumors. These results confirm consulted literature contributing for a criterious tumoral prognostic complementing the tumoral classification, providing a greater and better supervened due to adequacy of therapeutic procedure of each patient.
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Terzian, A. C. B., Zuccari, D. A. P. de C., Pereira, R. S., Pavam, M. V., Ruiz, C. M., Sueiro, F. A. R., & Coelho, J. (2007). Evaluation of caspase-3 and Ki-67 as a prognostic markers in canine mammary tumors. Brazilian Journal of Veterinary Research and Animal Science, 44(2), 96-102. https://doi.org/10.11606/issn.1678-4456.bjvras.2007.26647
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