Glyphosate-Roundup exposure delays puberty onset in male rats
Keywords:Puberty, Glyphosate, Endocrine disruptor
AbstractThe effects of herbicides and it's adjuvants can be responsible for several alterations in reproductive organs of male and female. Since glyphosate-Roundup penetrates in the cell, it reduces the activity of StAR protein and aromatase enzime. This study evaluated the development of pubertal characteristics in animals receiving oral dosages of glyphosate-Roundup by gavage, by daily body weight measurement and verification of preputial separation (PPS). 32 male rats were allocated in 4 groups of treatments (0, 5, 50 e 250 mg/kg) from 23 to 53 days of age. The body weight from 23 to 53 days was compared using analysis of MANCOVA, Kruskall-Wallis was used to compare the day at PPS and ANOVA was used to compare the body weight at PPS. Age at PPS was different between groups 50 mg/kg and 0 mg/kg (36,6±0,5; 36 days; p<0,05), 250 mg/kg and 0 mg/kg (37,2±0,4; 36 days; p<0,001) and 5 mg/kg and 250 mg/kg (36,5±0,5; 36 days; p<0,05). The body weight at PPS was higher in group of 250 mg/kg n comparison to groups of 0 mg/kg and 5 mg/kg (142,7 ± 9,3; 128,9 ± 5,4; 126,1 ± 8,8 g, respectively; p<0,001). The body weight of group 50 mg/kg (134,1 ± 9,2g) wasn't differ from another groups. Probably, the daily exposure to glyphosate-Roundup causes endocrine disruption in hypothalamic-pituitary-gonad axis during sexual maturation, because it delayed the onset of puberty.
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