Glyphosate-Roundup exposure delays puberty onset in male rats

Authors

  • Renata Marino Romano Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Reprodução Animal, São Paulo, SP
  • Marco Aurélio Romano Universidade Estadual do Centro-Oeste, Departamento de Farmácia, Guarapuava, PR
  • Maurício Osvaldo Moura Universidade Estadual do Centro-Oeste, Departamento de Biologia, Guarapuava, PR
  • Cláudio Alvarenga de Oliveira Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Reprodução Animal, São Paulo, SP

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.2008.26672

Keywords:

Puberty, Glyphosate, Endocrine disruptor

Abstract

The effects of herbicides and it's adjuvants can be responsible for several alterations in reproductive organs of male and female. Since glyphosate-Roundup penetrates in the cell, it reduces the activity of StAR protein and aromatase enzime. This study evaluated the development of pubertal characteristics in animals receiving oral dosages of glyphosate-Roundup by gavage, by daily body weight measurement and verification of preputial separation (PPS). 32 male rats were allocated in 4 groups of treatments (0, 5, 50 e 250 mg/kg) from 23 to 53 days of age. The body weight from 23 to 53 days was compared using analysis of MANCOVA, Kruskall-Wallis was used to compare the day at PPS and ANOVA was used to compare the body weight at PPS. Age at PPS was different between groups 50 mg/kg and 0 mg/kg (36,6±0,5; 36 days; p<0,05), 250 mg/kg and 0 mg/kg (37,2±0,4; 36 days; p<0,001) and 5 mg/kg and 250 mg/kg (36,5±0,5; 36 days; p<0,05). The body weight at PPS was higher in group of 250 mg/kg n comparison to groups of 0 mg/kg and 5 mg/kg (142,7 ± 9,3; 128,9 ± 5,4; 126,1 ± 8,8 g, respectively; p<0,001). The body weight of group 50 mg/kg (134,1 ± 9,2g) wasn't differ from another groups. Probably, the daily exposure to glyphosate-Roundup causes endocrine disruption in hypothalamic-pituitary-gonad axis during sexual maturation, because it delayed the onset of puberty.

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Published

2008-12-03

Issue

Section

UNDEFINIED

How to Cite

1.
Romano RM, Romano MA, Moura MO, Oliveira CA de. Glyphosate-Roundup exposure delays puberty onset in male rats. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2008 Dec. 3 [cited 2024 Jul. 14];45(6):481-7. Available from: https://www.revistas.usp.br/bjvras/article/view/26672