Cell proliferation in canine lymphoma

Authors

  • Sara Maria de Carvalho e Suzano Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Botucatu, SP
  • Julio Lopes Sequeira Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Clínica Veterinária, Botucatu, SP
  • Adriana Wanderley de Pinho Pessoa Universidade Estadual do Ceará, Fortaleza, CE
  • Camila Dias Porto Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Botucatu, SP
  • Deílson Elgui de Oliveira Universidade Estadual Paulista, Faculdade de Medicina, Departamento de Patologia, Botucatu, SP

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.2008.26691

Keywords:

Lymphoma, Canine, Proliferation, Ki-67, AgNORs

Abstract

Lymphoma studies deals with morphological classification and immunophenotypic features and they have to be amplified for cellular kinetics evaluation. This evaluation can only be safely made, when the proliferative index are evaluated. In men the proliferation index have, most of the time, important influence in the neoplasia prognosis and treatment In this work it was used 40 canine lymphomas that were classified according to Kiel methods and immunophenotype was achieved with CD3 (T lymphocyte) and CD79a (B lymphocyte). Cellular proliferation was evaluated by AgNORs and Ki-67 (MIB-1) According to Kiel classification system, high grade lymphomas were more frequent and T and B lymphoma showed the same frequency.When cellular proliferation was evaluated, there was a significant difference between high grade and low grade lymphomas by AgNOR and Ki-67 (MIB-1) methods, but did not differ when comparing immunophenotype. Among high grade malignancy lymphomas the NORs medium number per cell nucleoli was 1.37± 0.32 and in low grade was 0.98± 0.36, concerning Ki-67 the positive cellular percentual was 43.19% ± 19.01, e 14.09% ± 11.74 in high and low grade, respectively.

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Published

2008-08-01

How to Cite

Suzano, S. M. de C. e, Sequeira, J. L., Pessoa, A. W. de P., Porto, C. D., & Oliveira, D. E. de. (2008). Cell proliferation in canine lymphoma. Brazilian Journal of Veterinary Research and Animal Science, 45(4), 313-319. https://doi.org/10.11606/issn.1678-4456.bjvras.2008.26691

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